Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Cerium oxide/iron oxide/mesoporous silica nano composite material as well as preparation method and application thereof

A nanocomposite material, iron oxide nanotechnology

Active Publication Date: 2017-06-20
ZHEJIANG UNIV
View PDF4 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In addition to the absence of effective treatments, so far no markers specific for the clinical diagnosis of AD have been identified

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cerium oxide/iron oxide/mesoporous silica nano composite material as well as preparation method and application thereof
  • Cerium oxide/iron oxide/mesoporous silica nano composite material as well as preparation method and application thereof
  • Cerium oxide/iron oxide/mesoporous silica nano composite material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] (1) Synthesis and ligand conversion of cerium oxide nanocrystals: 0.4 g of cerium acetate hydrate and 3.2 g of oleylamine were added to 15 ml of xylene, stirred at room temperature for 4 hours, and raised to 90 degrees Celsius at a heating rate of 2 degrees Celsius per minute ; Inject 1ml of deionized water into the reaction system protected by an inert gas, age for three hours, precipitate with acetone, and centrifuge to obtain cerium oxide nanocrystals.

[0042] 15 mg of the synthesized cerium oxide nanocrystals, 0.5 g of 2-bromoisobutyric acid and 0.05 g of citric acid were sequentially added to a mixed solvent of 7.5 ml of chloroform and 7.5 ml of N,N-dimethylformamide and stirred for 24 hours. have to.

[0043] X-ray diffraction was performed on the obtained ligand-converted ceria nanocrystals, as shown in the attached figure 1 shown; and the morphology of ligand-converted cerium oxide nanocrystals was characterized by transmission electron microscopy, as shown in...

Embodiment 2

[0052] (1) Synthesis and ligand conversion of cerium oxide nanocrystals: 0.4 g of cerium acetate hydrate and 3.6 g of oleylamine were added to 15 ml of xylene, stirred at room temperature for 6 hours, and raised to 95 degrees Celsius at a heating rate of 2 degrees Celsius per minute ; Inject 1ml of deionized water into the reaction system protected by an inert gas, age for three hours, precipitate with acetone, and centrifuge to obtain cerium oxide nanocrystals.

[0053] 10 mg of the synthesized cerium oxide nanocrystals, 0.5 g of 2-bromoisobutyric acid and 0.05 g of citric acid were sequentially added to a mixed solvent of 7.5 ml of chloroform and 7.5 ml of N,N-dimethylformamide and stirred for 12 hours. have to.

[0054] (2) Synthesis and ligand conversion of iron oxide nanocrystals: 2 g of iron oleate, 1 g of oleic acid, and 2 g of oleyl alcohol were added to 10 g of octadecene. Stir at room temperature, and rise to 300 degrees Celsius at a heating rate of 10 degrees Celsi...

Embodiment 3

[0059] (1) Synthesis and ligand conversion of cerium oxide nanocrystals: 0.4 g of cerium acetate hydrate and 2.8 g of oleylamine were added to 15 ml of xylene, stirred at room temperature for 3 hours, and raised to 85 degrees Celsius at a heating rate of 2 degrees Celsius per minute ; Inject 1ml of deionized water into the reaction system protected by an inert gas, age for three hours, precipitate with acetone, and centrifuge to obtain cerium oxide nanocrystals.

[0060] 20 mg of the synthesized cerium oxide nanocrystals, 0.5 g of 2-bromoisobutyric acid and 0.05 g of citric acid were sequentially added to a mixed solvent of 7.5 ml of chloroform and 7.5 ml of N,N-dimethylformamide and stirred for 4 hours. have to.

[0061] (2) Synthesis and ligand conversion of iron oxide nanocrystals: 2g iron oleate, 1.2g oleic acid, and 2.5g oleyl alcohol were added to 10g octadecene. Stir at room temperature, and rise to 250 degrees Celsius at a heating rate of 10 degrees Celsius per minute...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to a cerium oxide / iron oxide / mesoporous silica nano composite material. The surfaces of amino-modified mesoporous silica nanoparticles are respectively modified by ligand-converted cerium oxide nanocrystals and ligand-converted iron oxide nanocrystals. The invention also relates to a preparation method and application of the cerium oxide / iron oxide / mesoporous silica nano composite material. Not only can the composite material carry a drug for treating Alzheimer apostrophe s disease (AD), but also can remove reactive oxide species (ROS) in AD-similar cells, and can be used for diagnosis of the AD as a nuclear magnetic resonance imaging contrast agent, thus realizing integration of diagnosis and treatment of the AD.

Description

technical field [0001] The invention belongs to the field of composite material preparation, and in particular relates to a cerium oxide / iron oxide / mesoporous silicon nanocomposite material and a preparation method and application thereof. Background technique [0002] Alzheimer's disease (Alzheimer's disease, AD), also known as senile dementia, is a neurodegenerative disease caused by impaired language, memory and reasoning of the brain hemispheres, and is the most common disease among the elderly. It is one of the diseases that seriously endanger human health. According to a world epidemiological survey in 2005, there are currently 24.3 million Alzheimer's patients in the world, with 4.6 million new cases each year (one new patient every 7 seconds). And this number will double every 20 years. By 2040, the total number may reach 81.1 million, and most of the patients are concentrated in developing countries. It is predicted that the number of Alzheimer's patients in my co...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/02A61K47/04A61K45/00A61K49/18A61K49/08A61P25/18
CPCA61K9/5115A61K45/00A61K49/08A61K49/183
Inventor 凌代舜杜阳李方园田梅张宏
Owner ZHEJIANG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com