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Grease for preventing complications of cardiovascular diseases of diabetes mellitus and preparation method and application thereof

A cardiovascular and complication technology, which is applied in the field of oil and its preparation for preventing the complications of diabetes and cardiovascular disease, and achieves the effects of reducing liver coefficient, preventing complications and improving liver function.

Inactive Publication Date: 2020-10-30
INST OF AGRO FOOD SCI & TECH SHANDONG ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In summary, so far no hypoglycemic drug has been proven to be effective in improving cardiovascular outcomes in patients with type 2 diabetes

Method used

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  • Grease for preventing complications of cardiovascular diseases of diabetes mellitus and preparation method and application thereof
  • Grease for preventing complications of cardiovascular diseases of diabetes mellitus and preparation method and application thereof
  • Grease for preventing complications of cardiovascular diseases of diabetes mellitus and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Peanut oil, olive oil, and chia seed oil were selected, and the fatty acid profile was determined by gas chromatography to determine the content of different fatty acids in various oils, and calculate the content of n-3 PUFA and n-6 ​​PUFA. According to the calculation ratio of fatty acid content in different oils, mix according to the ratio of peanut oil: olive oil: chia seed oil = 82:9:9, stir evenly, and prepare a blended oil with n-6 / n-3PUFA of 5.14:1 .

[0024] Fatty acid content in different oils:

[0025] peanut oil olive oil Chia Seed Oil blend oil SFA 26.40% 15.38% 11.35% 19.30% MUFA 42.82% 79.18% 8.16% 41.80% n-6 PUFA 30.77% 4.85% 19.81% 38.91% n-3 PUFA 0 0.60% 60.68% 6.34% n-6 / n-3 5.14: 1

[0026] Peanut oil, olive oil, and chia seed oil were selected, and the fatty acid profile was determined by gas chromatography to determine the content of different fatty acids in various oils, and calc...

Embodiment 2

[0030] Peanut oil, olive oil, and chia seed oil were selected, and the fatty acid profile was determined by gas chromatography to determine the content of different fatty acids in various oils, and calculate the content of n-3 PUFA and n-6 ​​PUFA. The blended oils with different n-6 / n-3 PUFAs were prepared by calculating the ratio of fatty acids in different oils.

[0031]

Embodiment 3

[0033] Animal experiments The oil prepared by the present invention can improve the diet of diabetic mice

[0034] Control group: n-6 / n-3 PUFA 50:1 group

[0035] Long-term intervention group: n-6 / n-3 PUFA is 5:1 group

[0036] Intermittent intervention group: n-6 / n-3 PUFA fed at 5:1 for 3 weeks, 50:1 for one week, and so on

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PUM

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Abstract

The invention relates to the field of health-care food, in particular to grease for preventing complications of cardiovascular diseases of diabetes mellitus, and the ratio of n-6 to n-3 PUFA of the grease is (4.5-5.5) 1. The grease can be applied to preparation of medicines for preventing complications of cardiovascular diseases of diabetes mellitus, or can be applied to preparation of health foodfor preventing complications of cardiovascular diseases of diabetes mellitus. As a diet, common symptoms of diabetic mice can be improved. Diet with the ratio of n-6 to n-3 PUFA being 4.5-5.5 1 increases the weight of diabetic mice, and the weight of the long-term intervention group and the weight of the intermittent intervention group are increased by 3.21% and 4.00% compared with a control group. As diet intervention, the composition can improve lipid metabolism disorder, reduce lipid deposition, significantly reduce AI and prevent diabetic cardiovascular disease complications.

Description

technical field [0001] The invention relates to the field of health food, in particular to an oil for preventing diabetic cardiovascular disease complications, a preparation method and application thereof. Background technique [0002] Various serious complications of diabetes are daunting, it can affect the patient's life expectancy and quality of life, and is the chief culprit causing disability and death of diabetic patients. Cardiovascular complications of diabetes include cardiac macrovascular disease and microvascular disease, cardiomyopathy, and cardiac autonomic neuropathy, which are the leading cause of death in diabetic patients. Coronary heart disease is the main major vascular complication of diabetes. Studies have shown that the risk of death from coronary heart disease in diabetic patients is 3-5 times higher than that in non-diabetic patients. The pathological mechanism is atherosclerosis, high blood sugar, high systolic blood pressure, high cholesterol, incr...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61P3/10A61P9/00A61P3/06A61P1/16A23L33/115A23L33/105A61K36/32A61K36/48
CPCA23V2002/00A61K36/32A61K36/48A61K36/537A23L33/105A23L33/115A61P1/16A61P3/06A61P3/10A61P9/00A61K2300/00A23V2200/328A23V2200/3262A23V2200/326A23V2200/32A23V2250/18A23V2250/21
Inventor 徐同成李娜刘玮邱斌宗爱珍贾敏杜方岭刘丽娜
Owner INST OF AGRO FOOD SCI & TECH SHANDONG ACAD OF AGRI SCI
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