Efficient extraction process of panax notoginseng multi-active-component spray freeze-dried powder and panax notoginseng multi-active-component buccal granules
A technology of spray freeze drying and active ingredients, applied in the field of natural products, can solve the problems of loss of heat-sensitive effective substances, single extraction substances, etc., and achieve the effects of increasing extraction effect, high extraction efficiency and good solubility
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[0073] The preparation method of the above-mentioned notoginseng multi-active ingredient mouth-dissolving granule comprises the following steps:
[0074] 1) Weighing 50-60% of the active ingredient of Panax notoginseng spray-freeze-dried powder, 20-40% of potato starch, 20-30% of erythritol and 1-2% of micro-powder silica gel according to mass percentage;
[0075] 2) Mix the active ingredients of notoginseng with spray freeze-dried powder, potato starch, erythritol and micropowdered silica gel, and at the same time use ethanol solution with a volume fraction of 85% to 95% to moisten it, and add it to a wet granulator for granulation; The obtained granules are dried at 40-60° C. to obtain mouth-dissolving granules with multiple active ingredients of notoginseng. The above-mentioned melt-in-the-mouth granules have no bad flavor, good solubility, and can be melted in the mouth.
[0076] The method described in the Pharmacopoeia was used to determine the total saponins in the Pan...
Embodiment 1
[0183] The extraction process of the active ingredient spray freeze-dried powder 1 of Panax notoginseng comprises the following steps:
[0184] 1) Weigh the coarse powder of notoginseng and place the coarse powder of notoginseng in a crushing equipment with a rotating speed of 2000r / min to pulverize for 3 minutes to obtain superfine powder of notoginseng with a particle size of 10 μm;
[0185] 2) Add water to Panax notoginseng fine powder at a mass ratio of 1:30, use citric acid / trisodium citrate to adjust the pH to 5, then add compound enzyme, and shake at a temperature of 60°C and a pH of 5 Heat the enzymolysis in a water bath for 3 hours. After the enzymolysis is completed, put the notoginseng enzymolysis solution in a boiling water bath for 5 minutes; cool down to room temperature after deactivation, and use a refrigerated centrifuge with a speed of 10,000r / min to separate for 10 minutes to obtain the supernatant and notoginseng slag; wherein, per gram of notoginseng fine ...
Embodiment 2
[0191] The extraction process of notoginseng active ingredient spray freeze-dried powder 2 comprises the following steps:
[0192] 1) Weigh the coarse powder of notoginseng and place the coarse powder of notoginseng in a crushing equipment with a rotating speed of 2000r / min to pulverize for 1min to obtain superfine powder of notoginseng with a particle size of 20 μm;
[0193] 2) Add water to Panax notoginseng fine powder at a mass ratio of 1:40, use citric acid / trisodium citrate to adjust the pH to 6, then add compound enzyme, and shake at a temperature of 40°C and a pH of 6 Heat the enzymatic hydrolysis in a water bath for 1 hour. After the enzymatic hydrolysis, inactivate the notoginseng enzymatic solution in a boiling water bath for 5 minutes; cool to room temperature after inactivating the enzyme, and use a refrigerated centrifuge with a speed of 10,000r / min to separate for 10 minutes to obtain the supernatant and notoginseng residue; wherein, per gram of notoginseng fine ...
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