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Long-acting compound anthelmintic liquid preparation as well as preparation method and application thereof

The technology of liquid preparation and medicine is applied in the field of long-acting compound anthelmintic medicine liquid preparation and preparation thereof, which can solve the problems of easy generation of drug resistance, weak effect of worm eggs, large dosage of medicine, etc., so as to expand the anti-insect spectrum and be difficult to recur. , the effect of increasing the killing rate

Active Publication Date: 2020-12-01
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention solves the problem that a single anthelmintic drug has a narrow anti-insect spectrum, a large dosage, and is prone to drug resistance; And the effect on insect eggs is weak. After a certain incubation period, the eggs will grow into larvae and adults, continue to infect the main body, and the recurrence rate is high. The technical problem that cannot meet the market demand is from the perspective of the whole to the part, macro to micro , compound and use antiparasitic drugs more reasonably, expand anti-parasitic spectrum, achieve better therapeutic effect, provide a long-acting compound anthelmintic drug preparation and its preparation method

Method used

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  • Long-acting compound anthelmintic liquid preparation as well as preparation method and application thereof
  • Long-acting compound anthelmintic liquid preparation as well as preparation method and application thereof

Examples

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Embodiment 1

[0033] Example 1 A long-acting compound anthelmintic drug liquid preparation and its preparation method

[0034] The composition and dosage of the long-acting compound anthelmintic drug liquid preparation:

[0035] Name of raw material Recipe 1 Milbexime 5g Albendazole 50g pyriproxyfen 30g Aluminum monostearate 10g Aluminum distearate 10g Tween 80 5g Lecithin 5g α-tocopherol 1g Ethyl oleate+N,N-dimethylformamide (1:1) Dilute to 1000mL

[0036] The preparation method of long-acting compound anthelmintic drug liquid preparation:

[0037] Preparation by high-temperature method: Take 700mL of ethyl oleate + N,N-dimethylformamide (1:1), and add ethyl oleate + N,N-dimethylformamide (1:1) at 130°C Add aluminum monostearate and aluminum distearate to 1) and keep for 1 hour, after aluminum monostearate and aluminum distearate are completely gelled; add α-tocopherol, dissolve and stir evenly, and cool rapidly to Bel...

Embodiment 2

[0038]Example 2 A long-acting compound anthelmintic drug liquid preparation and its preparation method

[0039] The prescription of long-acting compound anthelmintic drug liquid preparation:

[0040] Name of raw material Formation Milbexime 10g Fenbendazole 100g Dioxycarb 50g Aluminum monostearate 20g Tween 80 6g Lecithin 6g p-Hydroxy-tert-butylanisole 3g Soybean oil+N,N-dimethylformamide (1:1) Dilute to 1000mL

[0041] The preparation method of long-acting compound anthelmintic drug liquid preparation:

[0042] Preparation by high-temperature method: Take 700mL soybean oil + N,N-dimethylformamide (1:1), add soybean oil + N,N-dimethylformamide (1:1) at 130°C Add aluminum monostearate and keep it for 1 hour to completely gel the aluminum monostearate; add p-hydroxy tert-butyl anisole, dissolve and stir evenly, then cool rapidly to below 40°C, add Tween 80, lecithin, Bexime (particle size D90≤5μm), fenbendazole (p...

Embodiment 3

[0043] Example 3 A long-acting compound anthelmintic drug liquid preparation and its preparation method

[0044] The prescription of long-acting compound anthelmintic drug liquid preparation:

[0045] Name of raw material Formation Milbexime 8g Conbendazole 70g Methoprene 40g Aluminum distearate 10g Glyceryl Stearate 10g Span 40 5g Hydroxylated Lecithin 5g α-tocopherol + di-tert-butyl-p-cresol (BHT) (1:1) 2g ethyl oleate Dilute to 1000mL

[0046] The preparation method of long-acting compound anthelmintic drug liquid preparation:

[0047] Preparation by high-temperature method: Take 700mL of ethyl oleate, add aluminum distearate and glyceryl stearate to ethyl oleate at 130°C, keep for 1h, and make aluminum distearate, stearic acid After the glyceride is completely gelled; add α-tocopherol + di-tert-butyl-p-cresol (BHT) (1:1), dissolve and stir evenly, then cool rapidly to below 40°C, add Span 40, hydroxylat...

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Abstract

The invention relates to a long-acting compound anthelmintic liquid preparation as well as a preparation method and application thereof, and belongs to the field of veterinary drug preparations. The compound preparation is mainlycomposed of anti-parasitic active ingredients, namely milbemycin oxime, benzimidazoles and juvenile hormone ingredients, and comprises, in percent by mass, 0.5%-1% of milbemycin oxime, 5%-10% of benzimidazoles, 3%-5% of juvenile hormone, 0.1%-5% of macromolecule suspending agent, 0.1%-5% of wetting agent, 0.01%-1% of antioxidant and the balance of a dispersion medium.According to the invention, anti-parasitic drugs are combined for use, the insect-resistant spectrum is expanded, and a comprehensive and efficient in-vivo and in-vitro simultaneous-expelling effect is achieved.

Description

technical field [0001] The invention belongs to the technical field of veterinary drugs, and in particular relates to a long-acting compound anthelmintic drug liquid preparation and a preparation method and application thereof. Background technique [0002] Parasites can cause mechanical damage to pets by consuming nutrients in pets, causing pets to suffer from slow growth, stagnation, emaciation, anemia, and emaciation due to lack of nutrition; or miscarriage, stillbirth, loss of fertility; or rough skin, Dermatitis, itching, hair loss, weakness, decreased immunity, disease resistance, prone to diseases, infectious diseases, etc. After animals suffer from parasitic diseases, due to frequent contact with humans, most of the parasites can be transmitted to humans through pets, which seriously threatens the health of children and adults. [0003] Milbexime is a macrolide anti-endoparasite drug, mainly used as an anthelmintic for dogs; it can effectively prevent and control he...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/365A61K45/06A61K31/4184A61K31/4402A61K31/501A61K31/231A61K31/216A61K47/12A61K47/26A61K47/24A61K47/14A61K47/18A61K47/44A61K47/38A61K47/22A61K47/10A61K47/36A61K47/42A61P33/10A61P33/14
CPCA61K9/08A61K9/0019A61K31/365A61K45/06A61K31/4184A61K31/4402A61K31/501A61K31/231A61K31/216A61K47/12A61K47/26A61K47/24A61K47/14A61K47/18A61K47/44A61K47/38A61K47/22A61K47/10A61K47/36A61K47/42A61P33/10A61P33/14A61K2300/00Y02A50/30
Inventor 聂福贵李梁刘爱玲张朋丽李守军李亚玲吴燕子
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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