Biocompatible connecting element and method for producing biocompatible connecting element
A connecting component and biocompatible technology, applied in the field of spectral process control, can solve the problem of lack of real-time data in process control
Pending Publication Date: 2020-12-08
SCHOTT AG
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- Application Information
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Problems solved by technology
Despite these costs, process control is still adversely affected by the lack of real-time data, especially for single-use applications
Method used
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[0116] exist figure 1 and Figure 19 The connection element 10 shown in includes an outer frame 20 formed from a polymer such as polyetheretherketone (PEEK) and an inner part 30 formed as a one-piece transparent member 32 formed from a transparent material such as glass. .
[0117] This embodiment involves pressure polymerization, which can be produced, for example, by incorporating a transparent component 32 , in particular glass, into the polymer outer frame 20 under compressive stress.
[0118] To this end, the outer frame 20 formed as a polymer molding is heated (eg PEEK to 200° C.), a transparent member 32 formed in this example as a plate (with a larger diameter than the inner diameter of the port) is inserted and let cool. This results in an autoclavable and sterile-tight pressure polymerization.
[0119]The polymeric outer frame 20 has a flange 22, wherein the flange 22 is arranged on the first (proximal) tube end 20p. However, it is also possible to arrange the ...
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Abstract
In order to also provide spectral process control and / or real-time data, in particular in disposable bioreactors, the invention provides a biocompatible connecting element (10), in particular for useas a connection of a bioreactor, preferably a disposable bioreactor, in order to form a window into the bioreactor, the connecting element comprising: an outer frame (20) made of a polymer material orof a polymer material, in particular for connection to a wall of a bioreactor, in particular for inseparable connection to a wall of a disposable bioreactor; and an inner part (30), which has or is formed from a transparent material, such as glass, sapphire or glass ceramic, the inner part being accommodated in the outer frame in a sterile, preferably hermetically sealed, in particular non-separable manner and forming a window, in particular for enabling spectral process control from the outside of a bioreactor, and the invention also relates to a method for producing said connecting element.
Description
technical field [0001] The invention relates to a spectral process control in a production process in a bioreactor. Background technique [0002] Bioreactors are used for culturing microorganisms, animal and plant cells and thus open up a wide field of application for biotechnological production processes. There is a need to further optimize these processes in general. Especially for the manufacture of biopharmaceuticals it is necessary to improve the product yield and thus increase the profitability. In order to increase product yield, reduce the risk of contamination, and reduce costs, various options exist. [0003] On the one hand, the management of the process and thus the yield can be optimized by performing real-time process control of key parameters. Spectroscopic methods, which take measurements outside the bioreactor, are particularly suitable for this, since the risk of contamination is thereby avoided. [0004] In the case of bioreactors with stainless steel ...
Claims
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IPC IPC(8): C12M1/00C12M1/34C12M1/36C12M3/00
CPCC12M23/22C12M23/20C12M37/04C12M41/00C12M41/46C12M23/48C12M23/28B32B1/08B32B27/288B32B27/32B32B2307/412C08J7/08C08J2323/06C08J2371/10C12M23/02C12M23/46C12M23/06C12M31/02
Inventor C·奥特R·海特乐C·斯坦格尔H·布吕梅尔R·埃克
Owner SCHOTT AG