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Lactucin and application thereof as anti-inflammatory component

A technology of endocrine and lettuce, which is applied in the directions of anti-inflammatory agents, antipyretics, organic chemistry, etc., can solve the problems such as inability to extract endocrine, no application in anti-inflammatory aspects, etc., so as to inhibit the production of inflammation, Low cost and the effect of reducing pollution

Pending Publication Date: 2020-12-15
SHIHEZI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention overcomes the deficiencies of the prior art, provides a preparation method of radish bitterin and its application as an anti-inflammatory component, solves the problem that the prior art cannot extract radish bittern from chicory and does not have Anti-inflammatory application issues

Method used

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  • Lactucin and application thereof as anti-inflammatory component
  • Lactucin and application thereof as anti-inflammatory component
  • Lactucin and application thereof as anti-inflammatory component

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The preparation method of lettuce bitter element, comprises the steps:

[0044] S1: pretreatment: drying the chicory root in the air, and keeping the moisture content of the chicory root at 5%.

[0045] S2: Alcohol cold extraction: adopt cold extraction method, take 5 kg of dried chicory root, soak it with 4 times the amount of 95% ethanol for 5 times, each time for 3 days, collect the filtrate soaked each time, and collect the filtrate collected 5 times The filtrates were combined.

[0046] S3: Concentration: take the combined filtrate, and use a vacuum distillation device to distill off ethanol under the conditions of a pressure of 0.1 MPa and a temperature of 45° C. to obtain a thick extract of 0.3 g / ml.

[0047] S4: Extraction and purification: disperse 1 volume part of the thick extract into 3 volume parts of water to obtain a suspension; use 1 volume part of n-butanol to extract 1 volume part of the suspension, and take the water layer; Under the condition of 0....

Embodiment 2

[0057] The difference between this example and Example 1 is that: in step S2 alcohol cold extraction, the cold extraction method is used, and the dried chicory root is taken, soaked 5 times with 3 times the amount of 95% ethanol, 3 days each time, The filtrates from each soak were collected and the filtrates from the 5 collections were combined. The silica gel type of silica gel column I, silica gel column II and silica gel column III are all silica gel HF.

Embodiment 3

[0059] The difference between this example and Example 1 is that in step S2 alcohol cold extraction, the cold extraction method is used, and the dried chicory root is taken and soaked 5 times with 5 times the amount of 95% ethanol for 3 days each time. The filtrates from each soak were collected and the filtrates from the 5 collections were combined. The silica gel type of silica gel column I, silica gel column II and silica gel column III is silica gel G.

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Abstract

The invention relates to the technical field of biological medicines, and in particular relates to lactucin and application thereof as an anti-inflammatory component. According to the technical scheme, the preparation method of lactucin comprises the following steps: carrying out dehydration treatment on chicory roots, and then sequentially carrying out alcohol cold extraction, concentration, extraction purification and column chromatography purification. The application of the lactucin as the anti-inflammatory component comprises the following steps: carrying out dehydration treatment on chicory roots, then sequentially carrying out alcohol cold extraction, concentration, extraction purification and column purification to obtain the lactucin, and applying the lactucin to anti-inflammatorydrugs. The invention provides the preparation method of the lactucin and the application of the lactucin as the anti-inflammatory component, and solves the problems that in the prior art, a method for extracting the lactucin from chicory is unavailable and the lactucin is not applied to anti-inflammatory.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a lettucein and its application as an anti-inflammatory component. Background technique [0002] Chicory is a characteristic medicinal material in Xinjiang. It is native to the Mediterranean, Central Asia and North Africa, and is widely cultivated in Europe. The traditional Chinese medicine chicory has the effects of clearing the liver and gallbladder, invigorating the stomach and eliminating food, diuresis and swelling, antibacterial and anti-inflammatory. [0003] The anti-inflammatory research of the Uyghur medicine Chicory has made great progress, and the research results suggest that Chicory has good anti-inflammatory activity and can be widely used in various inflammatory diseases. However, compared with other traditional Chinese medicines, the research on the anti-inflammatory effect of Chicory has a certain lag. In previous studies, the anti-inflammatory effects of ...

Claims

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Application Information

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IPC IPC(8): C07D307/93A61P29/00
CPCC07D307/93A61P29/00
Inventor 秦冬梅邹楠蔡钢王淑秀苏林洁党婷
Owner SHIHEZI UNIVERSITY
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