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Universal method for the preparation of lipid-based coatings

A technology of base coating and lipid, applied in the general field of preparing lipid-based coating

Pending Publication Date: 2020-12-18
LIPOCOAT IP HLDG BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the next hurdle is to overcome a major bottleneck in the preparation of lipid coatings, namely the preparation of lipid (vesicle) solutions

Method used

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  • Universal method for the preparation of lipid-based coatings
  • Universal method for the preparation of lipid-based coatings
  • Universal method for the preparation of lipid-based coatings

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0081] Experiment 1 (control)

[0082]Experiment 1 was performed to demonstrate that the dilution factor of solution (A) in aqueous solution (B) was too high to produce a lipid-based coating. In order to investigate the excessively high dilution factor, the ethanol (absolute amount of ethanol ≥ 99.8% , VWR) to prepare solution (A) at a concentration of 50 mg / ml. Solution (A) was stored under argon at -20°C in microcentrifuge vessels (VWR) for up to 6 weeks. All lipids are ordered as powdered stock and stored under an argon atmosphere at -20°C for a maximum of 1 year. The aqueous solution (B) contained 0.1 M PBS buffer (Sigma-Aldrich), pH 7.4. In 1.5 mL of aqueous solution (B) at room temperature, 0.75 μL of solution (A) was added, thereby diluting to 0.025 mg of phospholipid per mL using a 2000-fold dilution factor. Solution (A) was dispensed into aqueous solution (B) using an air displacement P10 micropipette (Eppendorf). Stirring was performed using a benchtop vortex (l...

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Abstract

The invention relates to a process for making lipid-coated substrates comprising the steps of a. Providing a lipid solution (A) of phospholipids in a water miscible organic solvent at a phospholipid concentration between 25 and 450 mg / ml; b. Provide an aqueous solution (B) having p H between 4 and 8; c. Agitate the aqueous solution (B) and dispense the lipid solution (A) into the aqueous solution(B) to prepare an aqueous dispersion comprising lipid vesicles (C) having a number average size between 80 and 120 nm (measured according to dynamic light scattering) at a phospholipid concentration between 0.05 mg / ml and 2 mg / ml; and d. Applying the aqueous dispersion (C) to a substrate and formation of a lipid- based coating; wherein aqueous dispersion (C) contains at least 95 wt% water. The invention further relates to medical devices comprising a lipid-based coating, for example contact lenses and catheters.

Description

technical field [0001] The present invention relates to an easy-to-use method for preparing lipid-based coatings on substrates. Background technique [0002] Coating of substrates is known in the art. In general, a coating is a covering that can be applied to a substrate. Coatings can be, for example, decorative, functional, or both. Decorative coatings include, for example, lacquers and / or coatings. Functional coatings include, for example, adhesive, optical, catalytic, photosensitive, magnetic, electrical, conductive, insulating, odorant and / or protective. Functional (protective) coatings include, for example, anti-corrosion, scratch-resistant, water-resistant, anti-microbial, anti-inflammatory, anti-fouling, lubricious, hydrophobic, hydrophilic and / or bioactive. [0003] Coatings can be applied by methods such as vapor deposition, chemical and electrochemical techniques, spray coating, roll-to-roll coating processes, spin coating, and dip coating. Examples of vapor d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127B29D11/00C23C18/00
CPCA61K9/1271A61K9/1277A61L27/54A61L29/16A61L2300/22A61L2300/606A61L2300/62B29D11/00038B29D11/00865A61L29/08A61L31/08A61L31/16G02B1/10
Inventor J·范威德
Owner LIPOCOAT IP HLDG BV