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Layered double hydroxide material system, preparation method thereof and application of layered double hydroxide material system

A double hydroxide, hydroxide technology, applied in the direction of drug combination, pharmaceutical formula, non-active ingredient medical preparations, etc., can solve the problems of non-targeting, reduced toxic and side effects, and high drug resistance

Active Publication Date: 2020-12-22
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, infused chemotherapy is non-adhesive, non-targeting and low-permeable to tumor tissue
These lead to the need for a large number of multiple drug infusions, which easily lead to drug resistance and bring high toxic side effects and reduce the quality of life

Method used

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  • Layered double hydroxide material system, preparation method thereof and application of layered double hydroxide material system
  • Layered double hydroxide material system, preparation method thereof and application of layered double hydroxide material system
  • Layered double hydroxide material system, preparation method thereof and application of layered double hydroxide material system

Examples

Experimental program
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Embodiment 1

[0080]The preparation process of EDTA-loaded zinc aluminum layered double hydroxide (LDH / EDTA) is as follows: Weigh a certain amount of Zn(NO3)2·6H2O(0.594g), Al(NO3)3·9H2O(0.375g), NaNO3(0.085g) and cyclohexamethylenetetramine (HMT) (0.702g) were dissolved in 200mL of deionized water, magnetically stirred for 20min under the protection of high-purity argon atmosphere to exhaust the air, and then the solution was moved to a 120℃ oil bath Stir in the pot, reflux with high-purity argon as protective gas, and slowly add Na after 2h2H2EDTA solution (1.2mg dissolved in 50mL deionized water), continue to react at 80°C for 22h, finally the precipitate is collected by filtration and thoroughly washed with deionized water to obtain LDH / EDTA.

[0081]LDH / EDTA surface amination modification to obtain NH2-LDH / EDTA. The suspended hydroxyl groups on the surface of LDH are hydrolyzed and bonded to the silanic hydroxyl groups in APTES, and the surface is modified into suspended amino groups. The speci...

Embodiment 2

[0084]The preparation process of Zn-Al layered double hydroxide (LDH) is as follows: Weigh a certain amount of Zn(NO3)2·6H2O(0.594g), Al(NO3)3·9H2O(0.375g), NaNO3(0.085g) and cyclohexamethylenetetramine (HMT) (0.702g) were dissolved in 200mL of deionized water, magnetically stirred for 20min under the protection of high-purity argon atmosphere to exhaust the air, and then the solution was moved to a 120℃ oil bath Stir in the pot and reflux with cold water under the condition of high-purity argon as protective gas. After 2h, the temperature was changed to 80℃, and the reaction was continued for 22h. Finally, the precipitate was collected by filtration and thoroughly washed with deionized water to obtain LDH. The process of surface amination modification and NT connection in Example 2 is basically the same as that in Example 1, except that NT-LDH without EDTA is used. Among them, the loading mass of neurotensin in NT-LDH is 3.9 wt% of the mass of zinc aluminum layered double hydroxide...

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Abstract

The invention relates to a layered double hydroxide material system, a preparation method thereof and application of the layered double hydroxide material system, in particular to an NT-LDH / EDTA layered double hydroxide material and an NT-LDH layered double hydroxide material; the NT-LDH / EDTA layered double hydroxide material comprises the following components: ethylenediamine tetraacetic acid (EDTA)-loaded zinc-aluminum layered double hydroxide, and a neurotensin (NT) antibody modified on the surface of the zinc-aluminum layered double hydroxide.

Description

Technical field[0001]The invention relates to a layered double hydroxide material system and a preparation method and application thereof, in particular to an NT-LDH layered double hydroxide material and NT-LDH / EDTA layered double hydroxide material and preparation thereof Method and application, in particular to a surface-targeted modified zinc-aluminum layered double hydroxide (LDH) material system loaded with ethylenediaminetetraacetic acid (EDTA), a preparation method thereof, and a surface-targeted modified material The application of the system in the preparation of drugs for treating bladder cancer belongs to the technical field of medical bio-nano materials.Background technique[0002]Bladder cancer is one of the most common genitourinary system malignancies in the world. Its incidence ranks 12th among malignant tumors, and it has been gradually increasing in recent years. In clinical practice, 75% to 85% of patients with bladder cancer diagnosed for the first time are non-mus...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K31/198A61K47/68A61P35/00
CPCA61K47/6843A61K47/69A61K31/198A61P35/00
Inventor 鲍群群胡萍施剑林
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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