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A kind of green acid-modified cyclodextrin and preparation method thereof

A technology of cyclodextrin and acid modification, which is applied in the directions of non-active ingredients such as medical preparations, pharmaceutical preparations, and cosmetic preparations, can solve the problems of complicated operation and high production cost, and achieves simple preparation process and high encapsulation. The effect of efficiency

Active Publication Date: 2021-09-28
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most chemical modification methods involve the participation of toxic and harmful reagents, and the modification process is cumbersome, and the toxic and harmful reagents need to be removed additionally, resulting in high production costs

Method used

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  • A kind of green acid-modified cyclodextrin and preparation method thereof
  • A kind of green acid-modified cyclodextrin and preparation method thereof
  • A kind of green acid-modified cyclodextrin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Dissolution: Dissolve 1g of β-cyclodextrin, 1g of succinic acid, and 1g of sodium hypophosphite in 10mL of water completely;

[0034] (2) drying: drying the dissolved mixed solution obtained in step (1) in an oven at 100° C. for 3 hours to obtain a dried reactant;

[0035] (3) Reaction: react the dried reactant in step (2) at 140° C. for 12 minutes, and an esterification reaction occurs;

[0036] (4) Purification: Dissolve the reacted product in step (3) with 3 mL of water, then add 30 mL of absolute ethanol to precipitate the modified cyclodextrin, and wash the product twice with absolute ethanol;

[0037] (5) Drying: vacuum drying the acid-modified product purified in step (4) at 50° C. to obtain succinic acid-modified cyclodextrin.

[0038] The succinic acid modified cyclodextrin prepared in this embodiment 13 C NMR spectrum as figure 1 shown. It can be observed that a new characteristic peak appears at 16.68ppm in the cyclodextrin modified by succinic acid, ...

Embodiment 2

[0045] (1) Dissolution: Dissolve 1g of β-cyclodextrin, 1g of succinic acid, and 1g of sodium hypophosphite in 10mL of water completely;

[0046] (2) drying: drying the dissolved mixed solution obtained in step (1) in an oven at 100° C. for 3 hours to obtain a dried reactant;

[0047] (3) Reaction: react the dried reactant in step (2) at 140° C. for 20 minutes, and an esterification reaction occurs;

[0048] (4) Purification: Dissolve the reacted product in step (3) with 3 mL of water, then add 30 mL of absolute ethanol to precipitate the modified cyclodextrin, and wash the product twice with absolute ethanol;

[0049] (5) Drying: vacuum drying the acid-modified product purified in step (4) at 50° C. to obtain succinic acid-modified cyclodextrin.

[0050] The succinic acid modified cyclodextrin prepared in this embodiment 13 C NMR spectrum as figure 1 shown. It can be observed that a new characteristic peak appears at 16.68ppm in the cyclodextrin modified by succinic acid, ...

Embodiment 3

[0054] (1) Dissolving: Dissolve 4g of β-cyclodextrin, 4g of succinic acid, and 4g of sodium hypophosphite in 40mL of water completely;

[0055] (2) drying: drying the dissolved mixed solution obtained in step (1) in an oven at 100° C. for 3 hours to obtain a dried reactant;

[0056] (3) Reaction: The reactant after step (2) drying takes place esterification reaction under the microwave power of 320W, and reaction time is 45s;

[0057] (4) Purification: Dissolve the reacted product in step (3) with 12 mL of water, then add 120 mL of absolute ethanol to precipitate the modified cyclodextrin, and wash the product twice with absolute ethanol;

[0058] (5) Drying: vacuum drying the acid-modified product purified in step (4) at 50° C. to obtain succinic acid-modified cyclodextrin.

[0059] The succinic acid modified cyclodextrin prepared in this embodiment 13 C NMR spectrum as figure 1 shown. It can be observed that a new characteristic peak appears at 16.68ppm in the cyclodextr...

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Abstract

The invention discloses a green acid-modified cyclodextrin and a preparation method thereof, belonging to the field of modified cyclodextrins. Cyclodextrin and succinic acid are mutually modified through esterification reaction under catalyst conditions, and acid-modified cyclodextrin with different modification degrees can be obtained by controlling reaction time under high temperature or microwave action. The modified cyclodextrin prepared by the present invention does not involve the use of toxic and harmful reagents, the modification reaction is simple, green and controllable, and the loading capacity of the modified cyclodextrin to the guest molecules is significantly improved compared with the original cyclodextrin , has great application potential in food, medicine, cosmetics and other health fields.

Description

technical field [0001] The invention relates to a green acid-modified cyclodextrin and a preparation method thereof, belonging to the field of modified cyclodextrins. Background technique [0002] Cyclodextrin is a cyclic oligosaccharide with a hydrophobic inner cavity and a hydrophilic outer wall. This special molecular structure makes it have good loading properties for hydrophobic molecules. Many natural active ingredients and drug molecules have poor water solubility and are not resistant to light, heat, pH and other stimuli, which greatly weakens their application in functional foods and pharmaceuticals. Embedding these molecules with special functions into the cavity of cyclodextrin can effectively improve their water solubility and stability, thereby further improving their storage period and utilization in organisms. [0003] In order to improve the embedding effect of cyclodextrins on hydrophobic guest molecules, chemical modification methods are often used to modi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/16A61K47/69A61K8/73A23L29/30
CPCC08B37/0012C08B37/0015A61K47/6951A61K8/738A23L29/30B01J27/1806
Inventor 金征宇王金鹏胡瑶邱超田耀旗徐学明谢正军周星
Owner JIANGNAN UNIV