Preparation method of poly-6-hydroxyhexanoate

Abstract

The invention provides a preparation method of poly6hydroxyhexanoate, which comprises the following steps: mixing poly6-hydroxyhexanoate, a catalyst and alcohol, adding the mixture into a reactor, carrying out an esterification reaction at 40-300 DEG C for 1-5h, adding a water-carrying agent after the reaction is finished, and carrying out reduced pressure distillation to remove water, thereby obtaining poly6-hydroxyhexanoate. The method has the beneficial effects that (1) the technical steps are simple, the production cost is low, and the economic benefit is high; (2) no intermediate productis produced in the technology, other product water is easy to separate and has no influence on the environment, and the process safety coefficient is high; and (3) the yield of the poly6hydroxy hexanoate is more than 90%, the production effect is good, and the product quality is high.

Description

technical field [0001] The invention belongs to the chemical industry, and in particular relates to a preparation method of poly-6-hydroxycaproic acid ester. Background technique [0002] Poly-6-hydroxyhexanoate is a linear polyester, very soft, has great stretchability, and has good biodegradability and biocompatibility, it can be used as a drug carrier and degradable surgical suture The production raw material can also be compatible with macromolecules such as polyethylene, polypropylene, polycarbonate, and polyvinyl chloride, and can be copolymerized to prepare a variety of copolymers or blends with excellent properties. It is a very useful organic material. However, at present, there are few technical materials and literatures on the synthesis and production of poly-6-hydroxycaproic acid ester. When our research group explored the process conditions of poly-6-hydroxycaproic acid alcoholysis reaction, depolymerization under different conditions obtained respectively Meth...

AI Technical Summary

Problems solved by technology

However, at present, there are few technical materials and literatures on the synthesis and production of poly-6-hydroxycaproic acid ester. When our research group explored the process conditions of poly-6-hydroxycaproic acid alcoholysis reaction, depolymerization under different conditions obtained respectively Methyl 6-hydroxycaproate, ethyl 6-hydroxycaproate, propyl 6-hydroxycaproate, ethylene glycol 6-hydroxycaproate, ε-caprolactone and oligomers, of which 6-hydroxycaproic acid The yield of ethyl ester is the highest, reaching 87.006%. The yields of other 6-hydroxycaproic acid esters are all unsatisfactory, because the target product of poly6-hydroxycaproic acid alcoholysis is caprolactone, and 6-hydroxycaproic acid ester is alcohol The by-product of decomposing reaction, this is unstable as a kind of production technique of 6-hydroxycaproic acid ester, and the poly-6-hydroxycaproic acid ester yield of this technique is all more than 90%, and product component is simple and easy to separate, greatly Increased yield and productivity

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