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Specific NDRG2 degradation targeting peptide for improving stroke excitatory toxicity injury and application thereof

A specific, stroke-based technology that is applied in the field of biomedicine to achieve the effects of low synthesis cost, guaranteed transmembrane efficiency, and reduced inflammatory response

Active Publication Date: 2020-12-29
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Abstract
  • Description
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Problems solved by technology

At present, there are many brain-targeting strategies for drugs, which bring opportunities for the treatment of CNS diseases, but also face many challenges

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  • Specific NDRG2 degradation targeting peptide for improving stroke excitatory toxicity injury and application thereof
  • Specific NDRG2 degradation targeting peptide for improving stroke excitatory toxicity injury and application thereof
  • Specific NDRG2 degradation targeting peptide for improving stroke excitatory toxicity injury and application thereof

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Embodiment Construction

[0034] In order to enable those skilled in the art to better understand the solutions of the present invention, the following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only It is an embodiment of a part of the present invention, but not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present invention.

[0035]It should be noted that the terms "first" and "second" in the description and claims of the present invention and the above drawings are used to distinguish similar objects, but not necessarily used to describe a specific sequence or sequence. It is to be understood that the data so used are interchangeable under appropriate c...

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Abstract

The invention discloses a specific NDRG2 degradation targeting peptide for improving stroke excitatory toxicity injury and application thereof. A specific targeting peptide for rapidly and reversiblydegrading NDRG2 is constructed, wherein design and synthesis of three structural domains are included: (1) synthesizing a cell-penetrating structural domain (CMPD) by utilizing a known membrane-penetrating peptide fragment TAT; (2) specifically binding an NDRG2 structural domain (PBD); and (3) serially connecting a degradation structural domain (CTM / degron). The amino acid sequence of a functionalregion combined with the NDRG2 protein is shown as SEQ. ID. NO.1, the amino acid sequence of the lysosome and proteasome induced degradation peptide fragment is shown as SEQ. ID. NO.2, and the aminoacid sequence of the cell-penetrating peptide TAT is shown as SEQ. ID. NO.3.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a specifically degradable NDRG2 targeting peptide for improving excitotoxicity damage of cerebral apoplexy and its application. Background technique [0002] Stroke is the second most fatal and the most disabling disease in human beings, and its prevention and treatment has always been a difficult medical problem in the world. At present, the only proven effective treatment - tPA thrombolytic vascular recanalization therapy only benefits 5% of stroke patients due to the narrow treatment time window (4.5h), which greatly limits its scope of application, and reperfusion injury will also occur after vascular recanalization . In the past 20 years, a large number of gene therapy measures for the pathogenesis of ischemic brain injury (such as excitotoxicity, oxidative stress, inflammation, and apoptosis) reported by a large number of basic studies have failed due to th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K19/00A61K38/10A61K47/64A61P9/10A61P25/00A61P29/00
CPCC07K7/08A61P9/10A61P25/00A61P29/00C07K2319/10C07K2319/95A61K38/00
Inventor 侯武刚马玉龙王进郭海云张震赵建帅
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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