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Method for detecting content of powder components

A detection method and content technology, which is applied in the field of spectral detection, can solve the problem of not giving information about the content of the sample components to be tested, and achieve the effects of true and accurate detection results, high detection efficiency, and increased area coverage

Pending Publication Date: 2021-01-12
杭州健澄科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The trays are evenly spaced on the detection platform, and multiple items to be tested are placed at one time, and the Raman detection is carried out by pushing the trays. However, this detection is only through spectral detection, which gives the uniformity information of the powder sample, and does not Give information about the content of a certain component in the sample to be tested, especially in powder mixtures

Method used

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  • Method for detecting content of powder components
  • Method for detecting content of powder components
  • Method for detecting content of powder components

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Such as figure 1 As shown, the Raman detector 1 is used to detect the Raman spectrum of the sample to be tested such as simvastatin in rotation, the sample pool 2 is used to hold the sample to be tested such as simvastatin powder, and the rotating assembly 3 is used to treat The test sample is rotated and fixed.

[0044]When detecting the content of the active ingredients in the powder sample, firstly put the sample to be tested, such as simvastatin mixed powder, into the sample cell, and adjust the loading to be about 1 / 2 of the volume of the sample cell 2. The sample cell 2 is made of quartz and is connected to the rotating shaft of the rotating assembly 3. The diameter of the sample cell 2 and the rotating shaft are the same as a circle, and the position is adjusted so that the probe of the Raman spectrometer 1 is aligned with the lateral center of the sample cell 2. Set the wavelength of the Raman spectrometer to 532nm, the rotational speed of the rotating assembly...

Embodiment 2

[0050] According to the method of Example 1, the active ingredient content in the simvastatin mixed powder was detected. The difference is that the material of the sample cell 2 is glass, the sample loading is about 2 / 3 of the sample cell 2, the wavelength of the Raman spectrometer is 785nm, and the rotating speed of the rotating assembly is 1500r / min. The content of active ingredients in the body was detected. The result is similar to Example 1.

Embodiment 3

[0052] According to the method of Example 1, the active ingredient content in the simvastatin mixed powder was detected. The difference is that the material of the sample cell 2 is acrylic, the sample loading is about 2 / 3 of the sample cell 2, the wavelength of the Raman spectrometer is 633nm, and the rotating speed of the rotating assembly is 2000r / min. The content of active ingredients in the body was detected. The result is similar to Example 1.

[0053] The above experimental results show that the standard curve established by the method of the present invention can detect the content of active ingredients in the simvastatin mixed powder. Conducive to process control and management of product production.

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Abstract

The invention discloses a method for detecting the content of powder component,s which comprises the following steps: correcting a Raman spectrometer by using a standard substance, putting a sample tobe detected into a cuvette, connecting the cuvette to a rotating shaft of a rotating component, adjusting the position of the cuvette to enable the cuvette to be arranged at the front end of a probeof the Raman spectrometer, enabling the Raman light source to align to the transverse center of the cuvette; setting the emission wavelength of the Raman spectrometer, setting the rotating speed of the rotating component, enabling the sample to rotate, and monitoring a Raman spectrum in real time; inputting the collected Raman spectrum data into a PC software system for real-time analysis and processing; and judging the content of a certain component in the to-be-detected sample according to an analysis result. The detection of the method has real-time performance and accuracy, and the actualproduction requirements are quickly met.

Description

technical field [0001] The invention belongs to the technical field of spectral detection, and in particular relates to a method for detecting the content of powder components, in particular to a method for detecting the content of active components in a powder mixture by using Raman spectroscopy. Background technique [0002] The advent of the digital age has greatly changed people's work and lifestyle. Intelligentization and rapidity are the development goals of modern industrial production. During the production process, real-time monitoring, rapid identification, and sensitive detection of products are required. These requirements promote the rapid development of intelligent detection, and Raman spectroscopy technology is due to It is favored for its unique advantages. [0003] Raman spectroscopy uses the scattering phenomenon of light. When a beam of monochromatic light hits the surface of an object, there may be three destinations, a part of the light is transmitted, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65
CPCG01N21/65
Inventor 刘雅娇孙海林安志成李亚飞刘丽
Owner 杭州健澄科技有限公司