Application of 1,2,4 triazolo 4,3-B pyridazine derivative in preparation of anti-inflammatory factor storm drugs

Abstract

The invention discloses an application of a [1,2,4]triazolo[4,3-B]pyridazine derivative as shown in a formula (I) and a pharmaceutically acceptable salt or polymorphic substance thereof in preparationof anti-inflammatory factor storm drugs. According to the invention, the compounds can inhibit the expression and secretion of a variety of inflammatory factors by up-regulating let-7 expression, especially, expression and secretion of key factors IL-1RA, IL-1alpha, IL-1beta, IL-6, IL-10, IL-18, IL-22, IP-10, CCL2, GM-CSF, TNF-alpha and the like which form inflammatory factor storm, have good drug safety and strong inflammatory factor inhibition effect, and can be used as candidate drugs for resisting inflammatory factor storm.

Description

technical field

[0001] The technical field of medicine of the present invention, more particularly, relates to the application of 1,2,4 triazolo 4,3-B pyridazine derivatives in the preparation of anti-inflammatory factor storm drugs. Background technique

[0002] Inflammatory factors and cytokines are important humoral immune molecules, which can regulate various physiological functions of immune cells and organs to help the body resist foreign substances. Under normal circumstances, the expression of inflammatory factors and cytokines is strictly regulated by cells. However, factors such as viral infection or the side effects of certain drugs can cause disorder in the regulation mechanism of cellular inflammatory factors, resulting in excessive production of inflammatory factors and inflammatory factor storms. Inflammatory factor storm, also called "cytokine storm" or "hypercytokineemia", is a severe systemic inflammatory response. This reaction is manifested in the massiv...

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