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A kind of uterine cavity hemostatic balloon of composite chitosan and preparation method thereof

A technology of chitosan and chitosan solution, which is used in surgery, obstetrics and gynecology equipment, medical science and other directions, can solve the problems such as the inability to effectively reduce the probability of postoperative infection, the inability to completely eliminate the accumulation of fluid and blood, and to prevent Effects of intrauterine bleeding and infection, shortening compounding time and improving compounding efficiency

Active Publication Date: 2022-04-22
HEBEI AINENG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For this reason CN201520174285.0 discloses uterine hemostatic double balloons, although it can effectively carry out postpartum hemostasis, and can drain the accumulated blood and fluid in the uterine cavity and cervix at the same time, but it cannot completely eliminate the accumulated fluid and accumulated blood, and cannot be effective. Reduce the chance of postoperative infection

Method used

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  • A kind of uterine cavity hemostatic balloon of composite chitosan and preparation method thereof
  • A kind of uterine cavity hemostatic balloon of composite chitosan and preparation method thereof
  • A kind of uterine cavity hemostatic balloon of composite chitosan and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] (1) Preparation of balloon and silicone tube

[0049] The raw material of the balloon is silpuran6000-30A / B glue, which is injected and molded by a liquid silicone injection molding machine to obtain a silicone balloon; the raw material of the silicone tube is made of C6-165 glue, which is extruded by an extrusion molding machine to obtain a silicone tube;

[0050] (2) Assembly

[0051] Put the balloon on the silicone tube, use silpuran4200 glue, apply the glue evenly on the contact surface between the silicone tube and the balloon, let it stand for 36 hours after gluing, and obtain the silicone balloon catheter assembly after the glue is cured;

[0052] (3) Surface activation of silicone balloon catheter assembly

[0053] Dissolve 50ml of 3-aminopropyltriethoxysilane coupling agent in 500ml of hydrochloric acid solution with a pH of 3.5, stir to form an activation solution, and use a plasma cleaner to treat the silicone balloon catheter assembly obtained in step (2) f...

Embodiment 2

[0057] (1) Preparation of balloon and silicone tube

[0058] The raw material of the balloon is silpuran6000-30A / B glue, which is injected and molded by a liquid silicone injection molding machine to obtain a silicone balloon; the raw material of the silicone tube is made of C6-165 glue, which is extruded by an extrusion molding machine to obtain a silicone tube;

[0059] (2) Assembly

[0060] Put the balloon on the silicone tube, use silpuran4200 glue, apply the glue evenly on the contact surface between the silicone tube and the balloon, let it stand for 24 hours after gluing, and obtain the silicone balloon catheter assembly after the glue is cured;

[0061] (3) Surface activation of silicone balloon catheter assembly

[0062] Dissolve 50ml of 3-aminopropyltriethoxysilane coupling agent in 400ml of hydrochloric acid solution with a pH of 4.5, stir to form an activation solution, and use a plasma cleaner to treat the silicone balloon catheter assembly obtained in step (2) for...

Embodiment 3

[0066] (1) Preparation of balloon and silicone tube

[0067] The raw material of the balloon is silpuran6000-30A / B glue, which is injected and molded by a liquid silicone injection molding machine to obtain a silicone balloon; the raw material of the silicone tube is made of C6-165 glue, which is extruded by an extrusion molding machine to obtain a silicone tube;

[0068] (2) Assembly

[0069] Put the balloon on the silicone tube, use silpuran4200 glue, apply the glue evenly on the contact surface between the silicone tube and the balloon, let it stand for 48 hours after gluing, and obtain the silicone balloon catheter assembly after the glue is cured;

[0070] (3) Surface activation of silicone balloon catheter assembly

[0071] Dissolve 50ml of 3-aminopropyltriethoxysilane coupling agent in 600ml of hydrochloric acid solution with a pH of 3, stir to form an activation solution, and use a plasma cleaner to treat the silicone balloon catheter assembly obtained in step (2) for...

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PUM

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Abstract

The invention relates to a uterine cavity hemostatic balloon made of composite chitosan and a preparation method thereof. The capsule is made of silica gel. The specific method is to first perform plasma treatment on the surface of the balloon and the silica gel tube to add active hydroxyl groups on the surface of the silica gel, then cross-link the bridge molecules through the active hydroxyl groups, and finally combine the chitosan through the bridge molecules to form a surface. The silicone balloon and silicone tube of composite chitosan, the uterine cavity hemostatic balloon of composite chitosan provided by the present invention achieves uterine cavity hemostasis and anti-adhesion through the dual functions of balloon compression, anti-adhesion and antibacterial materials. , antibacterial effect, the method provided by the invention has short compounding time and high compounding efficiency.

Description

technical field [0001] The invention relates to a uterine hemostatic balloon compounded with chitosan and a preparation method thereof. Background technique [0002] At present, postpartum hemorrhage is the first cause of maternal death, which is usually secondary to severe postpartum hemorrhage due to uterine atony. The treatment of postpartum hemorrhage mainly includes drug therapy and Bakri balloon tamponade. Existing drugs mostly achieve hemostasis by helping the uterus to contract, and balloon tamponade is an international general compression hemostasis technique. Balloon tamponade is even more valuable when drug therapy fails. For this reason CN201520174285.0 discloses uterine hemostatic double balloons, although it can effectively carry out postpartum hemostasis, and can drain the accumulated blood and fluid in the uterine cavity and cervix at the same time, but it cannot completely eliminate the accumulated fluid and accumulated blood, and cannot be effective. Red...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B17/12A61B17/42C08J7/12C08L83/04
CPCA61B17/12022A61B17/12099A61B17/42C08J7/123C08J7/12C08J2383/04C08J2405/08A61B2017/12004A61B2017/4216
Inventor 刘丁文徐兰举杜亚东于月欣
Owner HEBEI AINENG BIOTECH CO LTD
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