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Melanin hair dye and use method thereof

A hair dye and melanin technology, applied in hair care, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of hair color change, unstable color of hair dye, fading, etc. The effect of short hair dyeing time

Inactive Publication Date: 2021-01-26
陕西中鸿科瑞再生医学研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The color of the existing hair dye is unstable, and the hair color is more likely to change or fade during the shampooing process

Method used

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  • Melanin hair dye and use method thereof
  • Melanin hair dye and use method thereof
  • Melanin hair dye and use method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A melanin hair dye, the preparation steps of which are as follows:

[0027] (1) Melanocyte culture: normal isolated primary human melanocytes (P3) were cultured with M254 medium, and when the cell confluence reached 90%, the cells were digested (0.25% trypsin), centrifuged (800rpm / min, After 5min), the cells were suspended in PBS, and then the suspension was irradiated with a UVB dose of 100mJ / cm2. After centrifugation, the culture was continued at a ratio of 1:2 for 24h, and then placed in a -80°C refrigerator for later use.

[0028] (2) Obtaining melanin granules: freeze-thaw the melanocytes obtained in step (1) repeatedly (3-4 times), collect the liquid, filter, acidify with citric acid, and centrifuge to obtain melanin granules as precipitates. (3) Preparation of melanin hair dye:

[0029] This hair dye includes three dosage forms, agent A: based on 100 parts by weight, add 5 parts of L-cysteine, 0.6 part of ascorbic acid (VC), 1 part of hydroxyethyl cellulose, 0.3...

Embodiment 2

[0034] A melanin hair dye, the preparation steps of which are as follows:

[0035] (1) Melanocyte culture: The normal isolated primary human melanocytes (P4) were cultured with M254 medium. When the cell confluence reached 90%, the cells were digested (0.25% trypsin), centrifuged (800rpm / min, After 5min), the cells were suspended in PBS, and then the suspension was irradiated with a UVB dose of 150mJ / cm2. After centrifugation, the culture was continued at a ratio of 1:2 for 36h, and then placed in a -80°C refrigerator for use.

[0036] (2) Obtaining melanin granules: The melanocytes obtained in step (1) were repeatedly frozen and thawed 4 times, the liquid was collected, filtered, acidified with citric acid, and centrifuged to obtain melanin granules as precipitates.

[0037] (3) Preparation of melanin hair dye:

[0038] This hair dye comprises three dosage forms, A agent: add 4 parts of L-cysteine, 0.8 part of ascorbic acid (VC), 0.8 part of guar gum, 2 parts of preservative...

Embodiment 3

[0043] A melanin hair dye, the preparation steps of which are as follows:

[0044] (1) Melanocyte culture: The normal isolated primary human melanocytes (p4) were cultured with M254 medium, and when the cell confluence reached 90%, the cells were digested (0.25% trypsin), centrifuged (800rpm / min, After 5min), the cells were suspended in PBS, and then the suspension was irradiated with a UVB dose of 150mJ / cm2. After centrifugation, the culture was continued at a ratio of 1:3 for 48h, and then placed in a -80°C refrigerator for use.

[0045] (2) Obtaining melanin granules: freeze-thaw the melanocytes obtained in step (1) three times, collect the liquid, filter, acidify with citric acid, and centrifuge to obtain melanin granules as precipitates.

[0046] (3) Preparation of melanin hair dye:

[0047] This hair dye includes three dosage forms, agent A: 4 parts of glutathione, 0.4 part of ascorbic acid (VC), 0.8 part of carboxymethylcellulose sodium, 1.5 parts of preservative ( ph...

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Abstract

The invention belongs to the field of cosmetics, and particularly relates to a melanin hair dye and a use method, the melanin hair dye comprises a combination of an agent A, an agent B and an agent C,the agent A is used as a hair pretreatment agent, disulfide bonds in hair are opened by using a penetrant, and subsequent metal ions and colorants can enter the hair. Metal ions in the agent B enterhuman hair and are complexed with amino acid in the hair firstly, then the agent C enters the hair and is complexed with the metal ions to form macromolecular melanin, hair scales are closed, and pigment is locked in the hair rod. When the product is used for hair dyeing, the hair dyeing effect is firm and stable, and the hair dye is natural and harmless, can be stored for 3 years at normal temperature in a sealed manner, and has the advantages of short hair dyeing time and low hair dyeing temperature.

Description

technical field [0001] The invention belongs to the field of cosmetics, and in particular relates to a melanin hair dye and a using method. Background technique [0002] Hair dyes refer to cosmetics that can change the color of hair and have special uses. The most used hair dyes for a long time are permanent and semi-permanent hair dyes. However, as the main component of oxidative hair dyes, traditional permanent hair dyes are also called oxidative hair dyes. The specific dyeing mechanism of this hair dye is to make the low molecular weight oxidation dye intermediates and other components penetrate into the middle of the hair, oxidize and polymerize in the hair to form macromolecular dyes and be locked in the hair. Oxidative hair dyes are almost all composed of three reactive compounds: dye intermediates, couplers (also known as coupling agents) and oxidants, especially p-phenylenediamine, which has been found to be an allergic substance that can cause allergic dermatitis,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/365A61K8/64A61K8/67A61Q5/10
CPCA61K8/365A61K8/64A61K8/676A61Q5/10
Inventor 明磊国王清霞李阿峰王哲
Owner 陕西中鸿科瑞再生医学研究院有限公司
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