Fused ring pyridone compound, preparation method and application
A technology of condensed ring pyridone and compound, applied in the field of medicinal chemistry, can solve the problems such as the failure to successfully develop targeted drugs and the small effect
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[0110] Embodiment General preparation method two
[0111]
[0112] Step 1: Dissolve the fused ring pyridone intermediate (1eq.) in anhydrous tetrahydrofuran, add DIPEA (1.6eq.) and piperazine intermediate (1.5eq.) in sequence, and heat to reflux for 18 hours under nitrogen protection . The reaction was complete as monitored by TLC, cooled to room temperature, and concentrated under reduced pressure. The residue was separated by adding water and dichloromethane. The aqueous phase was extracted three times with dichloromethane. The extract was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The target product was obtained by chromatography separation and purification, and its structure was confirmed by NMR and mass spectrometry.
[0113] The second step: dissolve the above-mentioned first step product (1eq.) in anhydrous glacial acetic acid, slowly add reduced iron powder (3eq.), and heat to 80 degrees under nitrogen protection and stir for 0.5 h...
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