Composition for preventing, alleviating or treating allergic skin diseases, containing, as active ingredient, extract of gardenia fruits from which pigments are removed

A technology of gardenia extract and active ingredients, applied in the field of compositions for preventing, improving or treating allergic skin diseases, can solve problems such as disease deterioration, increase the economic burden of patients, not belong to allergic diseases, etc. Effect

Pending Publication Date: 2021-02-09
KOREA INST OF ORIENTAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Allergy is a chronic disease in the field of modern medicine, so there is no clear cure so far
Although the antihistamines currently used are effective, they are not the basic treatment for allergic diseases in terms of treatment, and the use of steroids with many side effects can lead to further deterioration of the disease and continue to increase the economic burden on patients

Method used

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  • Composition for preventing, alleviating or treating allergic skin diseases, containing, as active ingredient, extract of gardenia fruits from which pigments are removed
  • Composition for preventing, alleviating or treating allergic skin diseases, containing, as active ingredient, extract of gardenia fruits from which pigments are removed
  • Composition for preventing, alleviating or treating allergic skin diseases, containing, as active ingredient, extract of gardenia fruits from which pigments are removed

Examples

Experimental program
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Effect test

preparation example Construction

[0025]The above-mentioned preparation method includes: step (1), adding an extraction solvent to Gardenia jasmine to carry out the first extraction and obtaining the first filtrate by filtering; step (2), after obtaining the first filtrate from the above step (1), , adding an extraction solvent to the remaining residue to obtain a second filtrate; step (3), after mixing the first filtrate obtained from the above step (1) and the second filtrate obtained from the above step (2), by adding activated carbon to make the pigment of the gardenia extract adsorbed on the activated carbon; and step (4), after the above step (3), removing the above activated carbon and obtaining the depigmented gardenia extract by filtering, concentrating and drying.

[0026] In the above step (3), there is no particular limitation on activated carbon, but preferably, it can be granular or fine-grained, and more preferably, it can be fine-grained (powder or powder form).

[0027] Preferably, the above-m...

Embodiment 1

[0037] Embodiment 1. Preparation of the gardenia extract that has removed pigment

[0038] In order to solve the problem of pigment remaining on the skin, activated charcoal was used to absorb gardenia pigment to remove the inherent pigment of gardenia, so as to prepare gardenia extract without crocin (Crocin).

[0039] (1) Preparation of Gardenia ethanol extract that has removed pigment

[0040] ① Preparation of Gardenia Extract for the First Time : After adding 100 g of gardenia to 1000 ml of 70% (v / v) ethanol and extracting in an aqueous solution at 55° C. for 2 hours, a first extract was obtained by filtration.

[0041] ② Preparation of Gardenia Extract for the Second Time : After adding 1000 ml of 70% (v / v) ethanol to the residue other than the above filtrate again and extracting under the same conditions as the first gardenia extract, a second extract was obtained by filtration.

[0042] ③ Pigment removal : Two types of activated carbon, carbon activated granular ...

Embodiment 2

[0051] Example 2. Confirmation of the effect on atopic dermatitis in an animal model of allergic atopic dermatitis coated with depigmented gardenia ethanol extract

[0052] Apply 100 mg of ointment (AD Biostir, Japan) containing natural house dust mite-derived components as an allergic atopy-inducing antigen to the skin of 8-week-old NC / Nga mice at intervals of 3 to 4 days and within 21 days A total of 6 applications were applied to induce allergic atopic dermatitis. Seven days after the induction of allergic atopic dermatitis, 1 mg / ml of drugs (gardenia extract (GJE1%), depigmented gardenia extract (GJE-CR 1%)) and tacrolimus (tarolimus) ) applied once a day for a total of 14 days.

[0053] Subsequently, once a week, each time 20 minutes, the number of times of scratching the ears and back of the mice induced by allergic dermatitis and the degree of skin damage were evaluated. All measurement results are expressed with mean (mean) and standard deviation (SD, standarddeviati...

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Abstract

The present invention relates to a composition for preventing, alleviating or treating allergic skin diseases, containing, as an active ingredient, an extract of gardenia fruit from which pigments areremoved. The extract of gardenia fruit from which pigments are removed is more effective in allergic skin diseases than extracts of gardenia fruit from which pigments are not removed, and thus can bevery effectively used for allergic skin diseases, especially, atopic dermatitis.

Description

technical field [0001] The present invention relates to a composition for preventing, improving or treating allergic skin diseases comprising depigmented gardenia extract as an active ingredient. Background technique [0002] Allergy refers to abnormal allergic reactions such as skin rash, itching, nasal discharge or sneezing in some people caused by the abnormality of the immune system. The World Health Organization (WHO) has listed allergic diseases as the 21st century seventh most problematic disease. The main allergic diseases are atopic dermatitis, asthma, rhinitis and so on. Allergy is a chronic disease in the field of modern medicine, so there is no clear treatment method so far. Although the currently used antihistamines are effective, they are not the basic treatment for allergic diseases in terms of treatment. Moreover, the use of steroids with many side effects can lead to further deterioration of the disease and continue to increase the economic burden of patie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/744A61K31/702A23L33/105A61P37/08A61P17/00
CPCA23L33/105A61P17/00A61K36/744A61P37/08A61K2236/00A61K31/702A23V2002/00A23V2200/304A23L5/23A23L5/273A23L33/40A61P17/04A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53B01D11/0288B01D15/125
Inventor 金镐京朴善幸张雪
Owner KOREA INST OF ORIENTAL MEDICINE
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