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Composition with lipid-reducing function and its preparation and preparing method

A technology of composition and pharmaceutical preparation, applied in the field of composition with lipid-lowering function and preparation and preparation thereof, can solve the problems such as preparation without literature report

Active Publication Date: 2007-06-13
北大世佳科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no literature report that royal rice oil is prepared into a lipid-lowering drug or a health product with lipid-lowering effect, and there is no literature report that royal rice oil and a traditional Chinese medicine composition are prepared together into a lipid-lowering drug or a health product with lipid-lowering effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 Preparation method of soft capsule containing only inactivated royal rice oil composition and its lipid-lowering effect

[0032] prescription:

[0033] Inactivated Royal Rice Oil 314g PEG400 314g made into 1000 capsules

[0034] Capsule material:

[0035] The weight ratio of gelatin: glycerin: water: PEG400 is 1:0.20:1:0.04.

[0036] The soft capsules are prepared by a conventional compression method, and the lipid-lowering function of the soft capsules prepared by this method is evaluated, and the animal model is hyperlipidemia rats.

[0037] 1. Test materials

[0038] Test sample: composition 1, which is the content of the above-mentioned soft capsule, that is, a mixture of royal rice oil and PEG400

[0039] Positive drug: Zocor, provided by Hangzhou Merck Pharmaceutical Co., Ltd., specification: 20mg×7 tablets / box, batch number: P1008.

[0040] Experimental animals: 60 Wistar rats, class II animals, half male and half female, weighing 70-80g

[0041] ...

Embodiment 2

[0065] Example 2 The preparation method of the soft capsule containing the composition of inactivated royal rice oil and hawthorn extract

[0066] Softgel Contents:

[0067] The weight ratio of inactivated royal rice oil: hawthorn extract: PEG400 is 1:0.5:1.5.

[0068] Capsule material:

[0069] The weight ratio of gelatin: glycerin: water: PEG400 is 1:0.50:1:0.10

[0070] The specific preparation method is as follows:

[0071] (1) Preparation of hawthorn extract: It can be prepared by water extraction and alcohol precipitation. Take the hawthorn medicinal material, add 8 times the amount of water to decoct 3 times, each time for 1 hour, filter, combine the filtrate, and concentrate to a relative density of 1.15 ( 60°C), add ethanol until the alcohol content reaches 70%, let it stand overnight, remove the precipitate, concentrate the filtrate, and dry it under reduced pressure to obtain the extract;

[0072] (2) Contents preparation: the above-mentioned extract and PEG400 ...

Embodiment 3

[0075] Example 3 The preparation method of the soft capsule containing the composition of inactivated royal rice oil and hawthorn extract

[0076] Softgel Contents:

[0077] The weight ratio of inactivated royal rice oil: hawthorn extract: PEG400 is 1:0.5:1.8

[0078] Capsule material:

[0079] The weight ratio of gelatin: glycerin: water: PEG400 is 1:0.25:1:0.08

[0080] Concrete preparation method is with embodiment 2.

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PUM

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Abstract

The present invention relates to a medicine composition with the function of reducing blood-lipid. It is characterized by that it contains inactivated pearl millet oil, crataegus extract and gardenia extract. Said medicine composition can be made into various dosage forms, such as capsule, tablet and others. Said invention also provides its preparation method and concrete steps.

Description

technical field [0001] The invention relates to a composition with lipid-lowering function and its preparation and preparation method, in particular to a composition containing royal rice oil and its preparation and preparation method, and provides the composition in the preparation of lipid-lowering medicine or health care use in the product. Background technique [0002] In "Compendium of Materia Medica", poppy seeds are called "Royal Rice, Elephant Valley, Sac", and have a sweet, flat, non-toxic smell. They are the seeds of the Papaveraceae plant, and the original plant is Papaver somniferum L. It is designated by the government unit Production. As early as the Tang and Song Dynasties, people discovered that poppy seeds have the effect of strengthening the body, and they are known as "plant brain gold" and "blood vessel scavenger". Therefore, local officials have always used poppy seeds as a high-quality royal tribute. [0003] Poppy seed oil is called "royal rice oil" ...

Claims

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Application Information

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IPC IPC(8): A61K36/66A61P3/06
Inventor 周亚伟
Owner 北大世佳科技开发有限公司
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