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Cosmetic composition based on platelet-rich plasma and andrias davidianus active peptide

A technology of platelet-rich plasma and cosmetic composition, which is applied in skin care preparations, medical preparations containing active ingredients, dressing preparations, etc., to reduce side effects, improve inhibition, and improve skin aging effects

Active Publication Date: 2021-02-12
成都高新区九州华昀医疗美容门诊部有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] So far, there is no report on the effective improvement of tyrosinase inhibition rate by combining dihydromyricetin with peptide active substances

Method used

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  • Cosmetic composition based on platelet-rich plasma and andrias davidianus active peptide
  • Cosmetic composition based on platelet-rich plasma and andrias davidianus active peptide
  • Cosmetic composition based on platelet-rich plasma and andrias davidianus active peptide

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Experimental program
Comparison scheme
Effect test

experiment example 1

[0021] The tyrosinase inhibition rate was determined by using equal amounts of dihydromyricetin, giant salamander active peptide, dihydromyricetin and giant salamander active peptide in a mass ratio of 1:1 mixture (mixture), and arbutin (control) as test substances .

[0022] The determination of tyrosinase inhibition rate is shown in Table 1. Shake No. 1, No. 2 and No. 3 well, keep the temperature in a water bath at 30°C for 10 minutes, add No. 4, shake for 10 minutes and immediately measure the absorbance value at 475 nm.

[0023] Tyrosinase inhibition rate=[(A 3 -A 4 ) / (A 1 -A 2 )]×100%.

[0024] Table 1

[0025]

[0026] The results of the determination of tyrosinase inhibition rate are shown in Table 2.

[0027] Table 2

[0028]

experiment example 2

[0030] Select 10 female facial beautifiers, aged 23-55, with varying degrees of facial skin sagging, pigmentation, dark yellow skin, and enlarged pores.

[0031] PRP preparation: Under aseptic conditions, 9~11ml of venous peripheral blood from facial beautifiers was extracted, and Swiss RegenLab platelet-rich plasma (PRP) preparation kit Type I (Type I Regen ACR®-C Plus, Switzerland REGENLAB SA company) , State Food and Drug Administration (Jin) No. 3661397, 2014), and operated according to the instructions of the set, 10 groups of 3~4ml platelet-rich plasma were obtained, and the plasma contained at least 4.1×10 8 / mL of platelets.

[0032] The obtained platelet-rich plasma was mixed with botulinum toxin, salamander active peptide, dihydromyricetin and normal saline to make a mixed solution. The final concentration of platelets in the mixed solution was 2.46×10 8 / mL~4.86×10 8 / ml, botulinum toxin is 5U / ml, the final concentration of giant salamander active peptide is 1 mg / ...

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Abstract

The invention discloses a cosmetic composition based on platelet-rich plasma and andrias davidianus active peptide, which is prepared by the following steps: mixing the platelet-rich plasma, botulinumtoxin, dihydromyricetin and andrias davidianus active peptide with normal saline to obtain a mixed solution, the concentration of the platelet-rich plasma in the mixed solution is 1*10<8> / mL<1>*10 <9> / mL and the botulinum toxin concentration is 120U / mL; wherein the concentration of dihydromyricetin is 0.1-2 mg / mL, the molecular weight of the andrias davidianus active peptide is less than 1000Da,and the concentration of the andrias davidianus active peptide is 0.1-1 mg / mL; and degerming the mixed solution by a 0.22 mu m filter membrane. The effect of botulinum toxin on improving skin aging isachieved, meanwhile, the side effect of botulinum toxin is effectively relieved, the effect lasting time can reach 9-12 months, and the phenomenon of facial stiffness does not occur in the whole process; under the combined action of dihydromyricetin and giant salamander active peptide, the inhibition effect on tyrosinase is effectively improved.

Description

technical field [0001] The invention relates to the technical field of cosmetic products, in particular to a cosmetic composition based on platelet-rich plasma and giant salamander active peptide. Background technique [0002] The color of human skin is related to the amount of melanin. Melanin is a metabolite of tyrosine and dopa, and tyrosinase catalyzes this process and is the key rate-limiting enzyme for melanin production. Therefore, tyrosinase inhibitors have been used in external whitening cosmetics and oral liquids, but Whitening takes effect slowly. In addition, during the growth process, aging phenomena such as wrinkles, stains and sagging will inevitably appear on the skin under the influence of the external environment. For this reason, people have also developed beauty products that inhibit aging. Studies have shown that injection of platelet-rich plasma (PRP) has a good skin repair effect, can effectively tighten loose skin, and lasts for a long time, but the...

Claims

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Application Information

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IPC IPC(8): A61K8/98A61K8/64A61K8/49A61Q19/08A61Q19/00
CPCA61K8/983A61K8/64A61K8/498A61Q19/00A61Q19/08A61K2800/782A61K2800/805A61K2800/592
Inventor 李伟佟长青翟兴月
Owner 成都高新区九州华昀医疗美容门诊部有限公司
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