CDK6/DYRK2 double-target inhibitor as well as preparation method and application thereof

A CH2, C1-C8 technology, applied in the field of CDK6/DYRK2 dual-target inhibitors and their preparation, can solve problems such as drug resistance
CN112390793AActive Publication Date: 2021-02-23JIANGSU TASLY DIYI PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
JIANGSU TASLY DIYI PHARMA CO LTD
Publication Date
2021-02-23

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Abstract

The present invention discloses a compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof. The invention also discloses a preparation method of the compound and application of the compound in prevention and / or treatment of cancers or tumor-related diseases, especially breast cancer, prostate cancer, lung cancer, multiple myeloma, leukemia, gastric cancer, ovarian cancer, colon cancer, liver cancer, pancreatic cancer, human glioma and other diseases. The compound provided by the invention is expected to be developed into a new generation of anti-cancer drugs.
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Description

technical field

[0001] The invention relates to the field of medicinal chemistry, in particular to a CDK6 / DYRK2 dual-target inhibitor and its preparation method and application. Background technique

[0002] Cyclin-dependent kinase 6 (CDK6 ) is a serine / tyrosine kinase that regulates the transition from the G1 phase to the S phase of the cell cycle. In the early stage of the G1 phase of the cell cycle, cyclin D binds to CDK6 and activates CDK6, and the formed cyclin D-CDK6 complex can promote the phosphorylation of retinoblastoma protein (Rb). Phosphorylation of Rb leads to the release of the transcription factor E2F, which accelerates the progression of the cell cycle from G1 phase to S phase. The up-regulation of the proto-oncogene CDK6 will lead to the acceleration of the process of cell cycle from G1 phase to S phase, resulting in the acceleration of cell cycle and cell proliferation. Uncontrolled cell proliferation is the main feature of cancer, therefore, the inhibit...

Claims

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