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Endometrial lotion and application thereof in treating endometritis

A technology for endometritis and endometrium, which is applied in the fields of medical formula, drug delivery, active ingredients of alkali/alkaline earth metal chloride, etc., and can solve problems such as inconvenient operation, large dose, and complicated prescription

Pending Publication Date: 2021-03-02
JILIN AGRICULTURAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the large-scale application of antibacterial drugs, drug-resistant strains are increasing, and the application of antibacterial drugs, hormones, etc. is inevitable or drug residues appear, which indirectly brings harm to human health.
However, traditional Chinese medicine preparations have complex prescriptions, inconvenient operation, large doses, and slow effects; therefore, providing a drug with good effect for treating animal endometritis, small side effects, and low cost has become an urgent problem to be solved.

Method used

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  • Endometrial lotion and application thereof in treating endometritis
  • Endometrial lotion and application thereof in treating endometritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1 Physiological saline lotion treatment of mice with endometritis

[0014] 1. Preparation of Normal Saline Wash

[0015] Select 8-10 weeks old healthy female virgin mice (SPF grade ICR mice) as healthy donors, inject 50 μL of normal saline into the mouse uterus under sterile conditions, and withdraw 30 μL of liquid from the uterus after staying for 2 minutes , to obtain normal saline washing solution of healthy mice. The obtained saline washing solution was stored at 4°C.

[0016] 2. Clinical trials

[0017] 1) Animal model

[0018] Take 20 SPF grade ICR mice, and perfuse each mouse into the uterus with a concentration of 1.0×10 10 After 25 μL of CFU / mL Escherichia coli, the mouse endometritis model was established successfully after 24 hours.

[0019] 2) Grouping and administration

[0020] The mice were randomly divided into two groups, 10 mice in each group, one group was used as the control group, and the other group was used as the treatment group. ...

Embodiment 2

[0023] Example 2 Physiological Saline Lotion Treating Cows with Endometritis

[0024] 1. Experimental animals

[0025] 20 sexually mature, unmated and non-physiological cows of similar age and body condition were selected from a dairy factory in Changchun City, Jilin Province, and were diagnosed as follows: 1) Check whether there is inflammatory secretion, If you see inflammatory secretions or traces of inflammatory secretions after discharge (oxtail, rump, and hocks are dirty with pus and scabs), it can be preliminarily confirmed that you have clinical endometritis; 2) rectal examination , check the position of the uterus, the shape of the uterine horns, the size and texture of the uterus, the contraction response, whether there is a corpus luteum in the ovary, and further determine the severity of the inflammation; If inflammatory secretions flow out, check the amount and character of pus to determine the nature and severity of inflammation. None of the 20 selected cows ha...

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Abstract

The invention discloses an endometrial lotion and application thereof in treating endometritis. The endometrial lotion is a normal saline lotion obtained by flushing the uterus of a healthy animal. The endometrial lotion is injected into the uterus suffering from endometritis, and the cure rate of a mouse escherichia coli endometritis model reaches 70%. Clinical tests show that the effective rateof bovine endometritis is 70%, and the cure rate is 60%.

Description

technical field [0001] The invention relates to the field of animal medicine, in particular to an endometrium lotion and its application in treating endometritis. Background technique [0002] For many years the uterus was considered sterile. However, since the mid-1980s, some studies have found bacteria in the uterus through bacterial culture analysis of endometrial samples, especially in recent years, the research and analysis of endometrial samples by high-throughput sequencing methods also showed The presence of bacteria in the endometrium suggests possible bacterial colonization in the uterus. Adverse reproductive health outcomes are often associated with bacterial colonization of the uterus, including choriovitis, pelvic inflammatory disease, endometritis, and others. [0003] Endometritis is a common obstetrical disease caused by postpartum bacterial infection in animals. It occurs mostly in cows, sows, dogs, etc., and it is extremely harmful to the reproductive per...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/14A61K9/00A61P15/00A61P31/04
CPCA61K33/14A61K9/0034A61P15/00A61P31/04
Inventor 吕文发王军赵静刘红羽杨雨江孙凯鑫徐高青王友元石丽颖李前庆
Owner JILIN AGRICULTURAL UNIV