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Preparation method of changtongshu granules

A granule and formula technology, applied in the field of medicine, can solve the problems of inconsistent granule color, difficult spray drying granulation process, etc., and achieve the effect of improving normal quality

Inactive Publication Date: 2021-03-19
JIANGXI JIMINKEXIN PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, the existing technology adopts the boiling process, which produces a large amount of water-extracted clear paste, which brings difficulties to the spray-drying granulation process, and sometimes the color of the particles does not meet the legal standards.

Method used

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  • Preparation method of changtongshu granules
  • Preparation method of changtongshu granules
  • Preparation method of changtongshu granules

Examples

Experimental program
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Effect test

Embodiment 1

[0074] Embodiment 1: 1250 parts by weight of Polygonum multiflorum, 833 parts by weight of Angelica sinensis, 833 parts by weight of Radix Paeoniae Rubra, 833 parts by weight of hemp seed, and 833 parts by weight of mulberry fruit, the steps are as follows: supercritical fluid extraction technology, extraction pressure 25Mpa, extraction temperature 35 degrees, The extraction time is 1 hour, and the flow rate of CO2 is 20 kg / hour. The extract is centrifuged, and the centrifugation parameters are as follows: the liquid temperature is 75-90°C, the centrifugal speed is 6900r / min, and the feeding speed is 2.0m3 / h. The centrifugate was concentrated to a relative density of 1.08 (60-70°C). After cooling to room temperature, add an equal amount of ethanol, stir well, let stand, take the supernatant and concentrate it into a clear paste with a relative density of 1.15-1.20 (60-70°C). Vacuum belt drying, vacuum belt drying parameters: heating system temperature 95°C in zone 1, 90°C in ...

Embodiment 2

[0075] Embodiment 2: 1250 parts by weight of Polygonum multiflorum, 833 parts by weight of Angelica sinensis, 833 parts by weight of Radix Paeoniae Rubra, 833 parts by weight of hemp seed, and 833 parts by weight of mulberry fruit, the steps are as follows: supercritical fluid extraction technology, extraction pressure 25Mpa, extraction temperature 35 degrees, The extraction time is 1 hour, and the flow rate of CO2 is 20 kg / hour. The extract is centrifuged, and the centrifugation parameters are as follows: the liquid temperature is 75-90°C, the centrifugal speed is 6900r / min, and the feeding speed is 2.0m3 / h. The centrifugate was concentrated to a relative density of 1.08 (60-70°C). After cooling to room temperature, add an equal amount of ethanol, stir well, let stand, take the supernatant and concentrate it into a clear paste with a relative density of 1.15-1.20 (60-70°C). Vacuum belt drying, vacuum belt drying parameters: heating system temperature 95°C in zone 1, 90°C in ...

Embodiment 3

[0076] Embodiment 3: Polygonum multiflorum 1250 parts by weight, Angelica 833 parts by weight, Radix Paeoniae Rubra 833 parts by weight, Hemp seed 833 parts by weight, Mulberry fruit 833 parts by weight, the steps are as follows: supercritical fluid extraction technology, extraction pressure 25Mpa, extraction temperature 35 degrees, The extraction time is 1 hour, and the flow rate of CO2 is 25 kg / hour. The extract is centrifuged, and the centrifugation parameters are as follows: the liquid temperature is 75-90°C, the centrifugal speed is 6900r / min, and the feeding speed is 2.0m3 / h. The centrifugate was concentrated to a relative density of 1.08 (60-70°C). After cooling to room temperature, add an equal amount of ethanol, stir well, let stand, take the supernatant and concentrate it into a clear paste with a relative density of 1.15-1.20 (60-70°C). Vacuum belt drying, vacuum belt drying parameters: heating system temperature 95°C in zone 1, 90°C in zone 2, 75°C in zone 3, 30°C...

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Abstract

The invention relates to a preparation method of changtongshu granules. The method comprises the following steps: a supercritical fluid extraction technique, with the extraction pressure 25Mpa, the extraction temperature 35 DEG C, the extraction time 1 hour, and the flow of CO2 20kg / hour; centrifugating the extraction solution, with the centrifugal parameters as follows: the temperature of the liquid medicine 75-90 DEG C, the centrifugal rotating speed 6900 r / min, and the feeding speed 2.0 m < 3 > / h; concentrating the centrifugate until the relative density is 1.08 (60-70 DEG C); after coolingto room temperature, adding the same amount of ethanol, uniformly stirring, standing, and concentrating the supernatant into clear paste with the relative density of 1.15-1.20 (60-70 DEG C); and conducting vacuum belt type drying, with the vacuum belt type drying parameters as follows: the temperature of a heating system 95 DEG C in a first zone, 90 DEG C in a second zone, 75 DEG C in a third zone and 30 DEG C in a fourth zone, the feeding speed 20L / h, the crawler speed 8HZ, then adding a proper amount of dextrin and steviosin to prepare 1000g of granules, and drying the granules to obtain the product.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine preparation, in particular to a preparation method of Changtongshu granules, a traditional Chinese medicine for soothing intestines and laxatives. It belongs to the field of medical technology. [0002] technical background [0003] Changtongshu granule is a Chinese patent medicine prepared by processing the five medicinal materials of Polygonum multiflorum, Angelica, Radix Paeoniae Rubra, Hemp Seed, and Mulberry. The functions and indications of Changtongshu Granules are as follows: nourishing yin and nourishing blood, moistening intestines and laxative. For habitual constipation, senile constipation and postpartum constipation embolism. [0004] The formula of Changtongshu Granules is as follows: [0005] It is prepared from 1250 parts by weight of Polygonum multiflorum, 833 parts by weight of Angelica sinensis, 833 parts by weight of Radix Paeoniae Rubra, 833 parts by ...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K36/704A61K9/16A61P1/10
CPCA61K9/1652A61K36/232A61K36/60A61K36/605A61K36/65A61K36/704A61K36/71A61K2236/37A61K2236/51A61K2236/53A61P1/10A61K2300/00
Inventor 范福圣胡锐敏彭常春刘慧星
Owner JIANGXI JIMINKEXIN PHARMA
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