AIE photosensitizer with different positive charges as well as preparation method and antibacterial application thereof

Abstract

The present invention relates to photosensitizers having aggregation-induced emission (AIE) properties and efficient singlet oxygen generation. They have a maximum absorption peak in the visible region of about 490 nm, with dark red / near infrared emission (> 650 nm). The antibacterial performance can be improved by adjusting the number of molecular charges of the AIE photosensitizer. The AIE photosensitizer provided by the invention can selectively image and kill bacteria, and does not influence mammalian cells. Under the irradiation of white light, the AIE photosensitizer with two positive charges has good antibacterial performance on gram-negative bacteria and gram-positive bacteria; in a dark field, the AIE photosensitizers with two positive charges also have good antibacterial performance on gram-positive bacteria. The AIE photosensitizer with a positive charge is an efficient antibacterial agent for gram-positive bacteria, and can efficiently inhibit the proliferation of gram-positive bacteria in mammalian cells in a dark field.

Description

technical field [0001] The present invention relates to a simple preparation method of a photosensitizer with aggregation-induced luminescent properties (AIE), relates to increasing the antibacterial properties of Gram-negative bacteria by increasing the number of positive charges of the AIE photosensitizer, and also relates to AIE photosensitizers as Gram An antibacterial agent for positive bacteria, it can also efficiently inhibit the proliferation of Gram-positive bacteria in cells in dark field. Background technique [0002] Humans have been battling bacteria for centuries. When antibiotics were first invented, their bactericidal effect was very efficient, but after a long period of abuse, some bacteria have developed drug resistance, which poses a great threat to our health. The World Health Organization has warned that in the near future we may be entering a post-antibiotic era where common infections and minor injuries can lead to serious morbidity and mortality. Th...

AI Technical Summary

Problems solved by technology

Although there have been some reports on the antibacterial application of cationic AIE photosensitizers, these studies rarely considered the effect of the number of positive charges on the antibacterial efficiency

Moreover, many reported AIE photosensitizers are highly phototoxic only to G(+) bacteria, but less phototoxic to G(-) bacteria

Images