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Drug delivery product, composition and system

A technology of conjugates and drug molecules, applied in drug combination, drug delivery, pharmaceutical formulation, etc.

Pending Publication Date: 2021-03-19
MASTER DYNAMIC LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, there has been concern about the use of delivery particles, such as nanoparticles, with problems related to toxicity and accumulation in the subject, as well as problems with aggregation to form such delivery particles, and thus the need for the drug to Efficient loading into particles and efficient and sustained delivery into the subject

Method used

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  • Drug delivery product, composition and system
  • Drug delivery product, composition and system
  • Drug delivery product, composition and system

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Embodiment Construction

[0052] invention (1.)

[0053] The present inventors have identified the disadvantages of drug delivery systems and have provided drug delivery products, compositions and systems having the following advantages:

[0054] (a) non-toxic drug delivery vehicle / particle,

[0055] (b) reduced particle aggregation,

[0056] (c) increased delivery system drug loading;

[0057] (d) providing a release mechanism at the site of the cancer;

[0058] (e) delivery and unloading of the drug compound or therapeutic agent at the site-specific treatment site; and

[0059] (f) Improved release rate and consistency of API delivery to a subject.

[0060] Against this background, the present inventors have developed a nanomedicine product using nanodiamond (ND), which can reduce adverse side effects and enhance the efficiency of drug delivery by using acid sensitivity.

[0061] According to the present invention, human serum albumin (HSA) was adhered on the surface of nanodiamond (ND) by physica...

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Abstract

The invention discloses a conjugate comprising (a) a nanodiamond; (b) human serum albumin (HSA) adhered on the surface of nanodiamond by physical adsorption; and (c) a drug molecule chemically linkedto said human serum albumin, wherein said drug molecule has a therapeutic effect.

Description

technical field [0001] The present invention relates to a drug delivery product, composition and system, and in particular, the present invention provides a drug delivery product, composition and system for delivering a drug with reduced toxic side effects to a subject. Background technique [0002] Chemotherapy is currently considered the most common cancer treatment in the world, yet the drugs typically come with associated side effects. [0003] In clinical practice, side effects remain a challenging issue in cancer therapy and treatment. Reducing side effects associated with a drug or therapy is an important issue, as this also encompasses the actual therapeutic effect of the drug. [0004] The design of drug delivery systems (DDS) can be used to address or at least ameliorate some of these side effect issues. DDS can include specific drug targeting / delivery, reducing toxicity while maintaining therapeutic efficacy, and developing new and safer drugs. [0005] Most ad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61P35/00A61K31/704A61K31/519
CPCA61P35/00A61K47/6929A61K47/6923A61K47/643
Inventor 郑嘉良
Owner MASTER DYNAMIC LTD