Method for preparing amine through catalytic reduction of nitro compound by cyclic (alkyl) (amino) carbene chromium complex

Abstract

The cyclic (alkyl) (amino) carbene chromium complex is prepared from corresponding ligand salt, alkali and CrCl3 and used for catalyzing pinacol borane to reduce nitro compounds in an ether solvent under mild conditions to generate corresponding amine. The method for preparing amine has the advantages of cheap and accessible raw materials, mild reaction conditions, wide substrate application range, high selectivity and the like, and is simple to operate.

Description

technical field [0001] The invention relates to a method for preparing amines by reducing nitro compounds. The method uses a cyclic (alkyl) (amino) carbene chromium complex as a catalyst, and reacts pinacol borane with nitro compounds to obtain corresponding amines. Background technique [0002] Amines are an important class of compounds, which have a wide range of applications in the fields of pesticides, medicines and materials. Therefore, the development of methods to prepare amines is of great significance for the development of new drugs and agrochemicals. At present, many popular medicines and agricultural chemicals on the market contain amino structural units, such as those with the following structural formulas: paracetamol, benzocaine, phenacetin, and p-aminosalicylic acid (prescription anti-tuberculosis drug). [0003] [0004] In industry, a simple and efficient method for synthesizing amines is the direct hydrogenation reduction of nitro compounds. The metho...

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Problems solved by technology

Catalytic hydrogenation has high efficiency, but hydrogen is a flammable gas, which is dangerous and requires high equipment requirements; the selectivity to functional groups such as olefins is poor

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