Antibacterial healing-promoting nano-fiber scaffold and nano-fiber scaffold patch prepared from same

Abstract

The invention relates to the technical field of medicine and pharmacology, in particular to an antibacterial healing-promoting nanofiber scaffold and a nanofiber scaffold patch prepared from the same. The antibacterial healing-promoting nanofiber scaffold comprises polyvinyl alcohol, silk fibroin, carboxymethyl cellulose and an antibacterial traditional Chinese medicine composition; and a nanofiber membrane with the fiber diameter of 100nm-500nm is prepared from the raw materials by adopting an electrostatic spinning method, and the nanofiber membrane is subjected to physical crosslinking treatment to prepare the antibacterial healing-promoting nanofiber scaffold. The nanofiber scaffold patch prepared from the nanofiber scaffold can remarkably improve the wound seepage absorption performance, a slowly-formed gel layer is applied to the wound, the minimum change of the microenvironment in the wound healing process can be guaranteed, drug slow release is facilitated, the healing period is shortened, and especially during change, secondary damage to the wound is avoided.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an antibacterial and healing-promoting nanofiber scaffold and a nanofiber scaffold paste prepared by using the scaffold. Background technique [0002] Chronic wounds are common in various clinical departments. The etiology is complex and the course of the disease is long. It has become a major problem in the new century. It not only has a significant negative impact on the quality of life of the patient himself, but also causes a medical burden on the society due to the high cost of dressing changes. It makes the wound more difficult to heal, and the difficult-to-heal wound can be infected concurrently. [0003] Medical dressings are one of the most common products in hospitals. They are materials used to cover wounds. They mainly include traditional dressings such as gauze and absorbent cotton and new-generation polymer material dressings. They can protect wounds from external ...

AI Technical Summary

Problems solved by technology

[0004] Existing medical dressings for wounds are difficult to balance changes in the microenvironment of the wound. Although they can protect the wound and reduce inflammation to a certain extent during use, they have poor absorption of wound exudate, and the wound exudate is easy to scab, especially when changing the dressing. In this case, due to the sudden separation of the dressing and the wound surface, it is easy to cause secondary damage to the wound surface, which in turn affects the healing of the wound surface, and it is difficult to achieve the antibacterial and anti-inflammatory effects before the wound surface is completely healed.

[0005] In addition, in order to increase the air permeability of dressings and wounds, there are also antibacterial fiber membrane products made by electrospinning technology. The fiber diameter is generally less than 100nm and the pursuit of smaller sizes, and the production process also tends to solve how to make this The thinner fiber membrane products are spun, and the resulting brittleness of the fiber membrane products must be remedied by subsequent chemical cross-linking preparation steps to ensure their strength.

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