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Traditional Chinese medicine extract for preventing and/or treating bronchitis

A bronchitis and extract technology, which is applied in the field of traditional Chinese medicine extracts for the prevention and/or treatment of acute bronchitis, and can solve the problems of side effects, low patient compliance, and large patients.

Pending Publication Date: 2021-05-14
上海绿谷生命园医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Bronchitis is often accompanied by many symptoms, such as cough, fever, inflammation, and (or not) bronchial secretions. There is no clinical drug that can simultaneously treat multiple or common accompanying symptoms of bronchitis. The existing In clinical medication, a combination of multiple drugs is often required to treat bronchitis and its complications. For example, for bronchitis, clinicians often give patients antipyretics, anti-inflammatory drugs, analgesics, antitussives, and antipyretics at the same time. Phlegm medicine, this way of administration not only results in low compliance of patients, but also takes multiple drugs at the same time, which is likely to have greater potential side effects on patients

Method used

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  • Traditional Chinese medicine extract for preventing and/or treating bronchitis
  • Traditional Chinese medicine extract for preventing and/or treating bronchitis
  • Traditional Chinese medicine extract for preventing and/or treating bronchitis

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0121] Preparation method of traditional Chinese medicine raw material medicinal material extract

[0122] Those skilled in the art can use conventional methods to extract the raw materials of traditional Chinese medicine. The extraction includes, but is not limited to: water extraction, alcohol extraction, hydroalcoholic solution extraction, CO2 supercritical extraction, aqueous solvent extraction, or a combination thereof.

[0123] The raw materials of traditional Chinese medicine can be mixed, and the active ingredients can be extracted by appropriate methods to obtain extracts; in addition, each raw material can also be extracted separately (such as using the same or different extraction or processing methods) active ingredients (that is, medicinal materials) extracts) were combined to obtain the extracts. It should be understood that the extracted active ingredients can exist in various forms, for example, the raw medicinal materials are extracted and purified to obtain ...

Embodiment 1

[0174] Chinese herbal extract preparation

[0175] Prescription and dosage

[0176]

[0177] Preparation

[0178] For the above five flavors, add 10 times the amount of 50% (v / v) ethanol aqueous solution, heat and reflux for extraction twice, each time for 2 hours, filter, and the filtrate is decompressed to recover ethanol and concentrate to a relative density of 1.02~1.12 (50~60℃ ) concentrated solution, the concentrated solution is diluted with purified water into a dispersion (containing crude drug amount 0.05kg / L), left standstill, (precipitation plus 95% (v / v) ethanol aqueous solution to make the alcohol content greater than or equal to 80% (v / v), take the supernatant and elute with 95% (v / v) aqueous ethanol). Take the supernatant of the dispersion liquid and load it on a styrene-type weakly polar macroporous adsorption resin column (AB-8 type). The diameter-height ratio of the resin column is 1:2.7, and the volume BV is 10.8L. Purified water was used to elute and...

Embodiment 2

[0183] Embodiment 2 investigates the pharmacological effect of the Chinese medicine extract preparation Qinsu capsule prepared in Example 1

[0184] Experimental Materials

[0185] The Chinese medicine extract preparation is the Chinese medicine extract preparation prepared in Example 1 (i.e. Qinsu capsule); Shuanghuanglian capsule is produced by Henan Tailong Pharmaceutical Co., Ltd., batch number 151021; endotoxin is produced by Beijing Dingguo Changsheng Biotechnology Co., Ltd. , batch number DH183-1; Suhuang Zhike Capsules, produced by Yangzijiang Pharmaceutical Group, batch number 17012011; Shuanghuanglian Capsules (4 capsules at a time, 3 times a day), Guangdong Huizhou Traditional Chinese Medicine Factory Co., Ltd., batch number 20180123;

[0186] In the experiment of Example 2, the capsule suspension is the content suspension in the capsule, that is, the Qinsu capsule suspension, the Shuanghuanglian capsule suspension, and the Suhuangzhike capsule are all the content s...

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Abstract

The invention relates to a traditional Chinese medicine extract for preventing and / or treating bronchitis. Specifically, the invention provides an application of a traditional Chinese medicine raw material or an extract thereof, the traditional Chinese medicine raw material or the extract thereof is used for preparing a pharmaceutical composition or a preparation, and the pharmaceutical composition or the preparation is used for (i) preventing and / or treating bronchitis; and / or (ii) preventing and / or treating symptoms caused by bronchitis; wherein the traditional Chinese medicine raw medicinal materials comprise one or more of the following medicinal materials: fructus perillae, caulis perillae, radix sophorae flavescentis, radix scutellariae and radix salviae miltiorrhizae. The traditional Chinese medicine raw material medicine or the extract thereof disclosed by the invention has an excellent treatment effect on bronchitis and symptoms thereof.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular, the invention relates to a traditional Chinese medicine extract for preventing and / or treating acute bronchitis. Background technique [0002] Bronchitis is an inflammation of the bronchial mucosa. The disease often involves the trachea and bronchi at the same time. It is clinically characterized by cough, fever, inflammation, and (or without) increased bronchial secretions. It is a common and frequently-occurring disease in clinical practice. According to statistics, the incidence of the disease in outpatient clinics is 20 times that of pneumonia and 10 times that of bronchial asthma. Most patients with acute bronchitis can recover by resting and drinking water, but if a few patients are not diagnosed and treated in time, they may develop sinusitis, pneumonia, otitis media, etc. If they persist, they may develop into chronic bronchitis, which will cause great harm to pa...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61P11/00A61P29/00
CPCA61K36/535A61K36/489A61K36/539A61K36/537A61P11/00A61P29/00A61K2300/00
Inventor 黄广伟孙仁弟杨素德马云飞杨瑞花张媛媛保红云韦悦高志泓张玥莉
Owner 上海绿谷生命园医药有限公司