Tetrandrine-loaded liposome preparation as well as preparation method and application thereof

A technology of tetrandrine and liposome preparations, which is applied in the field of tetrandrine-containing liposome preparations and its preparation, and can solve the problems of large impact on intraocular pressure and the like

Active Publication Date: 2021-05-25
CHONGQING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention intends to provide a tetrandrine-loaded liposome and its preparation method and application, so as to solve the problem that the existing anti-inflammatory drug preparations have a great influence on intraocular pressure when treating dry eye disease

Method used

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  • Tetrandrine-loaded liposome preparation as well as preparation method and application thereof
  • Tetrandrine-loaded liposome preparation as well as preparation method and application thereof
  • Tetrandrine-loaded liposome preparation as well as preparation method and application thereof

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Embodiment 1

[0027] A tetrandrine-loaded liposome preparation, comprising the following raw materials: soybean lecithin, dipalmitoyl phosphatidylethanolamine, cholesterol, tetrandrine and perfluorooctyl bromide, wherein soybean lecithin and dipalmitoyl phospholipid The mass ratio of the sum of the mass of acyl ethanolamine, cholesterol, and tetrandrine is 4:1:2.5~3.5, and the ratio of the amount of perfluorooctyl bromide to the amount of tetrandrine is 150μL:6mg~250μL : 6 mg.

[0028] A preparation method for tetrandrine-loaded liposome preparation, comprising the following steps:

[0029] S1. Dissolving soybean lecithin, dipalmitoyl phosphatidylethanolamine, cholesterol and tetrandrine in a solvent, and rotary evaporation to obtain a uniform thin liquid film; in this embodiment, soybean lecithin, dipalmitoyl phosphatidylethanolamine, Cholesterol and tetrandrine were taken 7mg, 1mg, 2mg, 6mg respectively, the solvent was chloroform, and the amount of chloroform was 10mL; the rotation spee...

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Abstract

The invention relates to the field of pharmaceutical preparations, and discloses a tetrandrine-loaded liposome preparation, which is prepared from the following raw materials: soya bean lecithin, dipalmitoyl phosphatidyl ethanolamine, cholesterol, tetrandrine and perfluorobromooctane, the mass ratio of the sum of the mass of the soybean lecithin and the dipalmitoyl phosphatidyl ethanolamine to the mass of the cholesterol to the tetrandrine is 4: 1: (2.5-3.5). The preparation method of the tetrandrine-loaded lipidosome preparation comprises the following steps: dissolving soybean lecithin, dipalmitoyl phosphatidyl ethanolamine, cholesterol and tetrandrine in a solvent, carrying out rotary evaporation to obtain a uniform thin liquid film, hydrating the thin liquid film, adding perfluorobromooctane, carrying out ultrasonic oscillation in an ice bath, centrifuging, collecting a precipitate, and obtaining the tetrandrine-loaded liposome preparation. The tetrandrine-loaded liposome preparation is applied to preparation of medicaments for treating dry eye diseases, has small influence on intraocular pressure, and greatly improves the entrapment efficiency and drug loading rate of tetrandrine.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a tetrandrine-loaded liposome preparation and its preparation method and application. Background technique [0002] Dry eye disease is a multifactorial disease with increased tear film permeability and ocular surface inflammation. Among the main strategies for the treatment of dry eye disease at present, artificial tears are the most commonly used in the treatment of dry eye disease because they can lubricate the eyes and relieve tear evaporation, and the side effects are small; because local anti-inflammatory drugs such as glucocorticoids can break the malignant Circulation, which greatly improves the symptoms and clinical signs of moderate to severe dry eye, is often combined with artificial tears and topical anti-inflammatory drugs. However, complications such as increased intraocular pressure and induced cataract formation with topical anti-inflammatory drugs limit...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K47/24A61K47/28A61K47/06A61K31/4748A61P27/02
CPCA61K9/127A61K9/1277A61K47/24A61K47/28A61K47/06A61K31/4748A61P27/02
Inventor 黄连弟杜之渝钟毅欣姚剑挺
Owner CHONGQING MEDICAL UNIVERSITY
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