Tetrandrine-loaded liposome preparation as well as preparation method and application thereof
A technology of tetrandrine and liposome preparations, which is applied in the field of tetrandrine-containing liposome preparations and its preparation, and can solve the problems of large impact on intraocular pressure and the like
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[0027] A tetrandrine-loaded liposome preparation, comprising the following raw materials: soybean lecithin, dipalmitoyl phosphatidylethanolamine, cholesterol, tetrandrine and perfluorooctyl bromide, wherein soybean lecithin and dipalmitoyl phospholipid The mass ratio of the sum of the mass of acyl ethanolamine, cholesterol, and tetrandrine is 4:1:2.5~3.5, and the ratio of the amount of perfluorooctyl bromide to the amount of tetrandrine is 150μL:6mg~250μL : 6 mg.
[0028] A preparation method for tetrandrine-loaded liposome preparation, comprising the following steps:
[0029] S1. Dissolving soybean lecithin, dipalmitoyl phosphatidylethanolamine, cholesterol and tetrandrine in a solvent, and rotary evaporation to obtain a uniform thin liquid film; in this embodiment, soybean lecithin, dipalmitoyl phosphatidylethanolamine, Cholesterol and tetrandrine were taken 7mg, 1mg, 2mg, 6mg respectively, the solvent was chloroform, and the amount of chloroform was 10mL; the rotation spee...
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