Ethers and esters of tertiary alkanols for use as aroma chemicals
A chemical, aroma technology, applied in the preparation of fragrances and essences, to prepare perfuming compositions or to change the aroma characteristics of perfuming compositions, synergistic effect to provide the possibility of better sensory attributes, to change the aroma characteristics of perfuming compositions It can solve the problems of difficulty in exploring new flavors and fragrances, material difficulties, and laboriousness, and achieve the effect of novel and favorable sensory attributes.
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[0463] abbreviation:
[0464] GC: gas chromatography
[0465] RT: retention time
[0466] DMAP:4-Dimethylaminopyridine
[0467] MTBE: methyl tert-butyl ether
[0468] analyze:
[0469] The purity of the product was determined on an area % basis by gas chromatography:
[0470] GC system: Agilent 7890B;
[0471] GC column: DB-WAX (30m (length), 0.32mm (ID), 0.25 micron (film));
[0472] Temperature program: 5°C / min from 85°C to 230°C
[0473] pass 13 C NMR identifies the product.
[0474] 1. Preparation Example
[0475] 1.1 Preparation of 3,4-dimethylpent-1-yn-3-ol
[0476] In a 5-liter autoclave, 308.5 g (5.5 mol) of sodium methoxide were suspended in 1500 ml of tetrahydrofuran and purged with nitrogen. The autoclave was pressurized at 10°C with 2 bar nitrogen and 18 bar acetylene. 5 moles of 3-methyl-2-butanone were added continuously over 16 hours at 10° C. while maintaining the pressure at 20 bar. The mixture was stirred at 0 °C for an additional 5 hours befo...
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