Application of 2-acyl-1-dimethylaminomethylferrocene derivative in preparation of drugs for targeted treatment of hepatocellular carcinoma

A technology of dimethylaminomethyl ferrocene and hepatocellular carcinoma, which is applied in the field of medicinal chemistry, can solve the problems of toxic side effects, poor targeting and selectivity of cancer cells, poor therapeutic effect of hepatocellular carcinoma, etc., and achieve growth inhibition, The effect of good selectivity
CN112870189AActive Publication Date: 2021-06-01HUAQIAO UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HUAQIAO UNIVERSITY
Publication Date
2021-06-01

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Abstract

The invention discloses an application of a 2-acyl-1-dimethylaminomethyl ferrocene derivative in preparation of a drug for targeted treatment of hepatocellular carcinoma. The structural formula of the 2-acyl-1-dimethylaminomethyl ferrocene derivative is shown in the specification, wherein R is halogen. The compound can induce apoptosis of tumor cells and inhibit growth of the tumor cells through active oxygen and cell cycle arrest, and has good selectivity.
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Description

technical field

[0001] The invention belongs to the technical field of medicinal chemistry, and specifically relates to the application of 2-acyl-1-dimethylaminomethyl ferrocene derivatives in the preparation of drugs for targeted treatment of hepatocellular carcinoma. Background technique

[0002] The global burden of hepatocellular carcinoma is increasing and may soon exceed the annual incidence of 1 million cases. Although 40%-50% of patients can receive early diagnosis and treatment through early detection, almost half of liver cancer will eventually develop into advanced liver cancer and receive systemic therapy for advanced liver cancer. However, the current drugs for the treatment of hepatocellular carcinoma have poor targeting and selectivity to cancer cells, accompanied by many serious side effects, resulting in poor therapeutic effect in the treatment of hepatocellular carcinoma. Therefore, it is particularly urgent to discover new, highly effective and less toxic...

Claims

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