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DNA single-molecule device capable of realizing intercalation recognition of adriamycin, and application thereof

A technology of DNA molecules and molecular devices, applied in the field of molecular electronics

Active Publication Date: 2021-06-01
CHINA UNIV OF GEOSCIENCES (WUHAN)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The difficulty in manufacturing cannot be broken through, which has become an insurmountable technical obstacle for silicon-based electronics, and Moore's Law will also encounter a bottleneck

Method used

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  • DNA single-molecule device capable of realizing intercalation recognition of adriamycin, and application thereof
  • DNA single-molecule device capable of realizing intercalation recognition of adriamycin, and application thereof
  • DNA single-molecule device capable of realizing intercalation recognition of adriamycin, and application thereof

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Embodiment Construction

[0017] Further illustrate the substantive content of the present invention below in conjunction with accompanying drawing and embodiment, embodiment is only in order to better understand the present invention but is not limited to the scope of the present invention, method in the embodiment is conventional method if no special instructions, the reagent used Unless otherwise specified, all reagents are commercially available or prepared according to conventional methods.

[0018] 1. Preparation steps: Clean the solvent bottle, solvent bottle, liquid pool, O-ring and spare gold-plated silicon substrate.

[0019] Soak the spare reagent bottle, solvent bottle, liquid pool, O-ring and gold-plated silicon substrate in a beaker filled with piranha lotion with a volume ratio of concentrated sulfuric acid: hydrogen peroxide = 3:1 for at least 2 hours, remove the reagent bottle, solvent Impurities on the surfaces of bottles, reservoirs, O-rings, and gold-plated silicon substrates. This...

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Abstract

The invention discloses a DNA single-molecule device capable of realizing intercalation recognition of adriamycin, and application thereof. According to the DNA single-molecule device capable of realizing intercalation recognition of adriamycin, the DNA single-molecule device takes a single-stranded DNA molecule as a recognition element, the sequence of the DNA molecule is ACGCGCGT, and the 3' end of the DNA molecule is modified with a sulfydryl group. According to the invention, an STM-BJ technology is utilized to detect the conductivity change of DNA molecular knots of intercalated DOX and non-intercalated DOX so as to realize the recognition of DOX. According to the invention, the DNA molecular knot with recognition and detection capabilities on drug molecules is designed and constructed by utilizing the characteristics of customizable sequence and length, easy chemical modification of molecular structure and the like of DNA molecules, and a novel strategy is provided for the subsequent research and development of high-specificity and high-sensitivity biological detection prototype devices based on the DNA molecular knot.

Description

technical field [0001] The invention relates to the technical field of molecular electronics, in particular to a DNA single-molecule device capable of intercalating and recognizing doxorubicin and its application. Background technique [0002] After years of development, the development of VLSI at this stage is facing great challenges. Issues such as strong electric fields, heat dissipation, and quantum effects have become particularly prominent under the market's continuous demand for reducing the size of silicon chips and increasing circuit integration. The difficulty in manufacturing cannot be broken through, which has become an insurmountable technical obstacle for silicon-based electronics, and Moore's Law will also encounter a bottleneck. In order to make substantive breakthroughs in electronic devices and integrated circuits, scientists began to jump out of the inherent "top-down (Top-down)" thinking, and turned to "bottom-up (Bottom-up)" thinking problem, molecular...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/06
CPCG01N27/06
Inventor 李辉靖乐洪文晶谢崇禹李少光夏帆
Owner CHINA UNIV OF GEOSCIENCES (WUHAN)