New application of vicenin 2 and vicenin 3

A technology of New Zealand vitexin and its application is applied in the new application field of New Zealand vitexin 2 and New Zealand vitexin 3, and can solve the problems of lack of anticoccidial drugs, reduced effect of anticoccidial drugs, etc.

Pending Publication Date: 2021-06-04
INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The prevention and treatment of chicken coccidiosis depends on the use of anticoccidial drugs. With the emergence of clinical wild poisonous strains resistant to traditional anticoccidial drugs, the effect of the original anticoccidial drugs is significantly reduced, making the lack of clinically effective drugs. Anticoccidiostats with clear therapeutic effect

Method used

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  • New application of vicenin 2 and vicenin 3
  • New application of vicenin 2 and vicenin 3
  • New application of vicenin 2 and vicenin 3

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] This embodiment provides the cell level test of New Zealand vitexin 2 and New Zealand vitexin 3, specifically as follows:

[0062] 1. Experimental materials:

[0063] (1) Drugs: Vitexin 2 from New Zealand, Vitexin 3 from New Zealand and sodium sulfachlorpyrazine were purchased from Merck.

[0064] (2) Coccidia oocysts: sporulated oocysts of Eimeria tenella (E. tenella) Guangdong strain, preserved by the Institute of Animal Health, Guangdong Academy of Agricultural Sciences, and rejuvenated in coccidia-free chicks before use.

[0065] (3) Cells: MDBK cells (ie, bovine kidney cells), preserved by the Institute of Animal Health, Guangdong Academy of Agricultural Sciences.

[0066] 2. Experimental method:

[0067] In this embodiment, the E.tenella MDBK cell culture model is used to evaluate the anti-Eimeria tenella (E.tenella) effect, and the specific evaluation steps include:

[0068] (1) Digest the MDBK cells growing to a fusion state of more than 80% with 0.25% trypsi...

Embodiment 2

[0097] This embodiment provides the animal level test of New Zealand vitexin 2 and New Zealand vitexin 3, specifically as follows:

[0098] 1. Experimental materials:

[0099] (1) Preparation of New Zealand Vitexin 2 powder: Take 1g of New Zealand Vitexin 2 (not less than 80%) and 99g of starch and mix; Preparation of New Zealand Vitexin 3 powder: Take 1g of New Zealand Vitexin Glycoside 3 (not less than 80%) and 99g starch are mixed.

[0100] (2) Control drug: conventional anticoccidial drug Sanzi coccidian powder (30% sodium sulfachlorpyrazine), produced by Shanghai Novartis Animal Health Co., Ltd.

[0101] (3) Coccidia oocysts: sporulated oocysts of Eimeria tenella (E. tenella) Guangdong strain, preserved by the Institute of Animal Health, Guangdong Academy of Agricultural Sciences, and rejuvenated in coccidia-free chicks before use.

[0102] (4) Chicks: Lingnan yellow broiler chickens, provided by the Institute of Animal Science, Guangdong Academy of Agricultural Science...

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Abstract

The invention relates to the technical field of animal disease prevention and control, in particular to new application of vicenin 2 and vicenin 3, and particularly relates to application of the vicenin 2 and the vicenin 3 in preparation of medicines or feeds for resisting coccidiosis. Compared with the prior art, the new new application has the following beneficial effects that the vicenin 2 and the vicenin 3 have an obvious inhibiting effect on the eimeria, and the inhibiting effect is reflected in that the vicenin 2 and the vicenin 3 can effectively inhibit the reproduction of the eimeria on a cell culture model of the eimeria, and moreover, the inhibitory effect is verified by animal body tests. Aiming at the discovery, the application fields of the vicenin 2 and the vicenin 3 are widened, and a new scheme is provided for development of anticoccidial drugs.

Description

technical field [0001] The invention relates to the technical field of animal disease prevention and control, in particular to a new application of New Zealand vitexin 2 and New Zealand vitexin 3. Background technique [0002] Vitexin 2 from New Zealand, also known as Wei Caining-2, has a molecular weight of 594.5, a CAS number of 23666-13-9, and a molecular formula of C 27 h 30 o 15 , the chemical structure is as follows: [0003] [0004] Vitexin 3 from New Zealand, also known as Wei Caining-3, has a molecular weight of 564.49, a CAS number of 59914-91-9, and a molecular formula of C 26 h 28 o 14 , the chemical structure is as follows: [0005] [0006] New Zealand vitexin 2 and New Zealand vitexin 3 are a class of flavonoid glycosides, which are distributed in leaves, stems, roots, bark, fruits and seeds of plants. Existing studies have shown that New Zealand vitexin 2 and New Zealand vitexin 3 have antioxidant, antiviral and anti-inflammatory effects. Accor...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P33/02A23K50/75A23K10/30
CPCA61K31/7048A61P33/02A23K50/75A23K10/30Y02A50/30
Inventor 孙铭飞廖申权戚南山林栩慧吕敏娜吴彩艳李娟蔡海明胡俊菁肖文婉于林增张小慧张健騑谢明权
Owner INST OF ANIMAL HEALTH GUANGDONG ACADEMY OF AGRI SCI
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