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Traditional Chinese medicine composition for treating diabetic nephropathy, traditional Chinese medicine preparation and preparation method thereof

A technology of diabetic nephropathy and composition, which is applied in the field of medicine and can solve problems such as poor pertinence

Inactive Publication Date: 2021-06-11
NANJING HOSPITAL OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the marketed Chinese patent medicines such as Xiaoke Pills and Yuquan Pills all focus on nourishing yin and clearing away heat, replenishing qi and promoting body fluid, and are less specific to diabetic nephropathy-related syndromes, and the curative effect needs to be further improved

Method used

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  • Traditional Chinese medicine composition for treating diabetic nephropathy, traditional Chinese medicine preparation and preparation method thereof
  • Traditional Chinese medicine composition for treating diabetic nephropathy, traditional Chinese medicine preparation and preparation method thereof
  • Traditional Chinese medicine composition for treating diabetic nephropathy, traditional Chinese medicine preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: Take 5g of raw Astragalus membranaceus, 20g of Codonopsis pilosula, 5g of cornus, 20g of Eupatorium, 5g of Alisma, 30g of cat’s claw, 10g of Smilax cocos, 20g of Caulis chinensis, 5g of Rhizoma chinensis, 20g of Trichosanthes sinensis, 5g of angelica, and 20g of curcuma , add water 16 times the weight of the medicinal material, decoct for 1 hour, filter, add water 8 times the weight of the medicinal material to the dregs, decoct for 1 hour, combine two decoctions, filter, concentrate the filtrate, and vacuum dry , to obtain dry extract powder, add dextrin, wet granules with 80% ethanol, and dry the wet granules at 60°C to obtain granules.

Embodiment 2

[0028] Example 2: Take 30g of raw Astragalus membranaceus, 5g of Codonopsis pilosula, 20g of cornus, 5g of Eupatorium, 20g of Alisma, 5g of cat's claw, 40g of Smilax smilax, 5g of Caulis chinensis, 20g of Rhizoma chinensis, 5g of Trichosanthes sinensis, 20g of angelica, 5g of curcuma , add 16 times the amount of water by weight of the medicinal material, decoct for 1 hour, filter, add water of 8 times the weight of the medicinal material to the dregs, and decoct for 1 hour, combine the decoction twice, filter, concentrate the filtrate, and vacuum dry. Obtain the dry powder of the extract, add starch, make granules, and compress into tablets to obtain tablets.

Embodiment 3

[0029] Example 3: Take 30g of raw Astragalus membranaceus, 15g of Codonopsis pilosula, 10g of cornus, 12g of Eupatorium, 10g of Alisma, 30g of cat’s claw, 40g of Smilax cocos, 12g of Caulis chinensis, 15g of Rhizoma chinensis, 15g of Trichosanthes sinensis, 12g of angelica, 10g of curcuma , add 16 times the amount of water by weight of the medicinal material, decoct for 1 hour, filter, add water of 8 times the weight of the medicinal material to the dregs, decoct for 1 hour, combine two decoctions, filter, concentrate the filtrate, and spray dry. Obtain the dry powder of the extract, add dextrin to make granules, dry, and pack into capsules to obtain capsules.

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PUM

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Abstract

The invention provides a traditional Chinese medicine composition for treating diabetic nephropathy. The traditional Chinese medicine composition is prepared from 5-30 parts of raw radix astragali, 5-20 parts of radix codonopsis, 5-20 parts of prepared fructus corni, 5-20 parts of herba lycopi, 5-20 parts of rhizoma alismatis, 5-30 parts of radix ranunculi ternati, 10-40 parts of rhizoma smilacis glabrae, 5-20 parts of caulis piperis futokadsurae, 5-20 parts of rhizoma dioscoreae nipponicae, 5-20 parts of radix trichosanthis, 5-20 parts of radix angelicae sinensis and 5-20 parts of rhizoma curcumae. The invention further provides a traditional Chinese medicine preparation prepared from the traditional Chinese medicine composition and a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine composition is complete in monarch, minister, assistant and guide, rigorous in compatibility and complementary, has the effects of reinforcing the kidney, dispelling wind, removing turbidity and harmonizing collaterals, has a remarkable effect of improving clinical syndromes of the diabetic nephropathy, can reduce serum creatinine, urea nitrogen and urine protein of patients with the diabetic nephropathy, has a good kidney protection effect and has a good application prospect.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a traditional Chinese medicine composition, a traditional Chinese medicine preparation and a preparation method thereof for treating diabetic nephropathy. Background technique [0002] Diabetic nephropathy (diabetic nephropathy, DN) is a common chronic complication of type 1 and type 2 diabetes mellitus. The main clinical manifestations are chronic hyperglycemia, proteinuria and progressive renal dysfunction, and it has a high disability rate. The pathogenesis of diabetic nephropathy has not yet been elucidated clearly. At present, it is believed that genetic factors, hemodynamic changes, inflammatory cell infiltration, glucose metabolism disorder and tissue hypoxia can all lead to diabetic nephropathy. In recent years, the incidence of diabetic nephropathy in my country has been increasing, and it has become the main cause of end-stage renal disease, second only to glomerulon...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P3/10A61P13/12
CPCA61K36/481A61K36/344A61K36/40A61K36/53A61K36/884A61K36/71A61K36/90A61K36/896A61K36/67A61K36/8945A61K36/428A61K36/232A61K36/9066A61P3/10A61P13/12A61K2236/331A61K2300/00
Inventor 郑艳辉
Owner NANJING HOSPITAL OF T C M
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