Compound with aggregation-induced emission property as well as preparation method and application thereof

An aggregation-induced luminescence and compound technology, which is applied in the field of multifunctional organic small molecule synthesis, can solve the problems of weakening fluorescence intensity and reducing the efficiency of reactive oxygen species, and achieve the effect of high production efficiency and long emission wavelength.

Active Publication Date: 2021-06-11
SHENZHEN UNIV
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Problems solved by technology

[0006] In view of the above-mentioned deficiencies in the prior art, the object of the present invention is to provide a compound with aggregation-induced luminescent properties and its preparation method and application, aiming at solving the problem that existing traditional photosensitizers are prone to weakening of fluorescence intensity and activity in the aggregation state. The problem of decreased oxygen production efficiency

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  • Compound with aggregation-induced emission property as well as preparation method and application thereof
  • Compound with aggregation-induced emission property as well as preparation method and application thereof
  • Compound with aggregation-induced emission property as well as preparation method and application thereof

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Embodiment Construction

[0062] In order to make the object, technical solution and advantages of the present invention more clear and definite, the present invention will be further described in detail below with reference to the accompanying drawings and examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0063] The compounds with aggregation-induced luminescent properties provided in the examples of the present invention have molecular structural formulas as follows:

[0064]

[0065] Specifically, where R 1 , R 2 each independently selected from H,

[0066] The compound with aggregation-induced luminescence properties described in the present invention is a type I aggregation-induced luminescence photosensitizer, which has better hypoxia resistance and can more effectively utilize the limited oxygen in the tumor microenvironment in the process of PDT, improving Effects of photod...

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Abstract

The invention relates to a compound with aggregation-induced emission property as well as a preparation method and application thereof, the compound has a molecular structural formula, and R1 and R2 are respectively and independently selected from one of H and a group shown as the specification. The compound with the aggregation-induced emission property, provided by the invention, has relatively long absorption and emission wavelengths, the emission wavelength can reach a near-infrared light region, and the compound has efficient I-type ROS generation efficiency. The compound with the aggregation-induced emission property, provided by the invention, can be used for targeting tumor cell nucleus imaging after being wrapped by a cell nucleus targeting carrier to form nanoparticles. Therefore, the material can be used for tumor cell nucleus targeted photodynamic therapy.

Description

technical field [0001] The invention relates to the technical field of synthesizing multifunctional organic small molecules, in particular to a compound with aggregation-induced luminescence properties and a preparation method and application thereof. Background technique [0002] Photodynamic therapy (PDT), as a new and effective cancer treatment method, has attracted much attention due to its unique advantages of high spatio-temporal precision, controllability, non-invasiveness, and low side effects. At present, most organic photosensitizers mainly generate type II reactive oxygen species (such as singlet oxygen, 1 o 2 ) mainly, 1 o 2 The production of tumors is highly dependent on oxygen, and the hypoxic characteristics of the tumor site are not conducive to 1 o 2 The main effect of PDT is exerted, and the loss of oxygen in the process of PDT will further reduce the curative effect. [0003] Type I photosensitizers can use the dismutation reaction regulated by super...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/46C09K11/06A61K41/00A61P35/00G01N21/64
CPCC07D307/46A61K41/0057A61P35/00C09K11/06G01N21/6428C09K2211/1088C09K2211/1007C09K2211/1014
Inventor 王东康苗苗张志军
Owner SHENZHEN UNIV
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