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High-toughness hydrogel based on PHEMA as well as preparation method and application of the high-toughness hydrogel

A hydrogel and high-toughness technology, applied in medical science, prosthesis, tissue regeneration, etc., can solve the problems such as the inability to induce tissue regeneration, and achieve adipogenic differentiation, high fracture toughness, and biophase good capacitive effect

Pending Publication Date: 2021-06-11
WEST CHINA HOSPITAL SICHUAN UNIV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Even the developed high toughness hydrogels do not yet have the ability to induce tissue regeneration

Method used

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  • High-toughness hydrogel based on PHEMA as well as preparation method and application of the high-toughness hydrogel
  • High-toughness hydrogel based on PHEMA as well as preparation method and application of the high-toughness hydrogel
  • High-toughness hydrogel based on PHEMA as well as preparation method and application of the high-toughness hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1, the preparation of hydrogel of the present invention

[0048] Dissolve hydroxyethyl methacrylate (HEMA) and maleic anhydride (MA) with a molar ratio of 8:1 in water, that is, dissolve 8 mol HEMA and 1 mol MA in 30 mL of water, and blow nitrogen into the solution for 10 min while stirring to remove the Oxygen, then add 0.0003mol photoinitiator 2-hydroxyl-2-methyl propiophenone (1173), light reaction 2h under the ultraviolet lamp that wavelength is 365nm, power is 300W, obtains P (HEMA-co-MA) water Gel A, denoted as P(HEMA-MA)A.

Embodiment 2

[0049] Embodiment 2, the preparation of hydrogel of the present invention

[0050] Dissolve hydroxyethyl methacrylate (HEMA) and maleic anhydride (MA) with a molar ratio of 8:2 in water, that is, dissolve 8 mol HEMA and 2 mol MA in 30 mL of water, and blow nitrogen into the solution for 10 min while stirring to remove the Oxygen, then add 0.0003mol photoinitiator 2-hydroxyl-2-methyl propiophenone (1173), light reaction 2h under the ultraviolet lamp that wavelength is 365nm, power is 300W, obtains P (HEMA-co-MA) water Gel B, denoted as P(HEMA-MA)B.

Embodiment 3

[0051] Embodiment 3, the preparation of hydrogel of the present invention

[0052] Dissolve hydroxyethyl methacrylate (HEMA) and maleic anhydride (MA) with a molar ratio of 8:3 in water, that is, dissolve 8 mol HEMA and 3 mol MA in 30 mL of water, and blow nitrogen into the solution for 10 min while stirring to remove the Oxygen, then add 0.0003mol photoinitiator 2-hydroxyl-2-methyl propiophenone (1173), light reaction 2h under the ultraviolet lamp that wavelength is 365nm, power is 300W, obtains P (HEMA-co-MA) water Gel C, denoted as P(HEMA-MA)C.

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Abstract

The invention provides high-toughness hydrogel based on PHEMA as well as a preparation method and application of the high-toughness hydrogel, and belongs to the technical field of high polymer materials. The structure of the hydrogel is shown as a formula I, and x is 100-200; y is from 50 to 100; and z is in a range of 200 to 300. The hydrogel with a uniform cross-linked network structure and hydrogen-bond interaction is obtained by copolymerization of hydroxyethyl methylacrylate and maleic anhydride. The hydrogel has relatively high fracture toughness and can meet the requirements of being used as a substitute material for breasts and the like; meanwhile, thehydrogel has low elastic modulus, and stem cell adipogenic differentiation can be induced easily; in addition, the hydrogel is good in biocompatibility and has the effect of promoting growth of breast related cells. The hydrogel has excellent mechanical properties and biocompatibility, and can promote growth of breast related cells, so that the hydrogel can overcome the defects of existing breast substitute materials and the like, a breast substitute material with more excellent performance is prepared, and the hydrogel has a good application prospect.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a PHEMA-based high-toughness hydrogel and a preparation method and application thereof. Background technique [0002] Mastectomy or atrophy deprives a woman of her physical beauty and can lead to a range of psychological and social responses. The development of tissue engineering has made breast regeneration and repair possible. Polymer hydrogel has broad application prospects in human tissue and organ replacement materials due to its water content similar to that of the human body, and has also become a potential breast replacement material. [0003] In order to ensure that hydrogels are used as human tissue and organ replacement materials, the hydrogels are required to be tough enough to support the mechanical load from the surrounding tissues. In recent years, various hydrogels with high toughness have been developed, but most hydrogels have poor biocom...

Claims

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Application Information

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IPC IPC(8): C08F220/20C08F222/06C08F2/48A61L26/00A61L27/16A61L27/52
CPCC08F220/20C08F222/06C08F2/48A61L27/16A61L27/52A61L26/0014A61L26/008A61L2430/04A61L2430/34C08L35/00
Inventor 刘勇王义赵丽娟吴锦荣伍俊良易龙飞宋永娇欧阳宏妍罗星琪谢袁杰
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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