Method and system for monitoring a set-up for manufacture of a biopharmaceutical product

Abstract

The present disclosure relates to a system and method (10) for monitoring a set-up for manufacture and / or setting up for manufacture and / or tearing down after manufacture of a biopharmaceutical product. The method comprises: processing (S2, S3, S4) at least one image of a scene comprising the set-up for manufacture of the biopharmaceutical product. The processing of the at least one image comprises performing (S2) a first process on the at least one image for classifying first objects in the image, said first objects being devices such as clamps, pumps, valves and / or sensors and / or any other bio processing equipment. The first process comprising identifying, localizing and classifying the first objects in the image. A second process is performed (S3) on the at least one image for identifying and localizing connections in the images. The second process comprises classifying each pixel with an associated second object classifier, said second object classifier classifying a second object selected from a group comprising the first objects and connections, segmenting out pixels associated with a connection and identifying connection mappings with the first objects. The method further comprises forming (S4) compiled information comprising information relating to the identified connection mappings obtained from the second process and the first objects as identified by the first process.

Description

technical field [0001] The present disclosure relates to an image / video frame based method for monitoring a set-up for the manufacture of a biopharmaceutical product. Background technique [0002] The past decade has seen a major shift in the nature of products manufactured and marketed by the innovative biopharmaceutical industry. Today's global biopharmaceutical portfolio reflects greater ubiquity of large molecule drugs, expansion in the number of individualized or targeted products, and the rise of treatments for many orphan diseases. These developments provide biopharmaceutical products with extremely limited production runs, high specific manufacturing requirements, and genotype specific products. Ongoing shifts in product mix provide the need for continuous improvements in the efficiency and effectiveness of producing biopharmaceutical manufacturing. [0003] Biomedicines (also known as biologics) such as, for example, therapeutic proteins, monoclonal antibodies, va...

AI Technical Summary

Problems solved by technology

However, adaptation to single-use technology also implies higher throughput and flow of materials (i.e., SUT consumables) in the production process and facility compared to conventional manufacturing with fixed stainless steel installations

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