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Preparation process of novel catalyst for isobutylbenzene synthesis process

A technology for the synthesis of isobutylbenzene and isobutylbenzene, applied in the directions of physical/chemical process catalysts, chemical instruments and methods, chemical/physical processes, etc., can solve problems such as expensive metal potassium, unfavorable industrial application, and reduced production costs, and achieve Facilitate procurement, improve market competitiveness, and reduce production costs

Inactive Publication Date: 2021-06-15
山东新华万博化工有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The side chain alkylation reaction requires the use of alkali metals as catalysts. At present, metal potassium catalysts or potassium-sodium alloy catalysts are widely used at home and abroad, but metal potassium is expensive, which is not conducive to industrial applications. If it can be replaced by cheaper metal sodium Catalyst will greatly reduce production costs

Method used

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  • Preparation process of novel catalyst for isobutylbenzene synthesis process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Potassium carbonate is placed in a stainless steel tray, placed in a muffle furnace to heat up and dry, the temperature is controlled at 200°C, and the drying time is 1 hour. After drying, it is pulverized with a pulverizer, sieved with a sieve, and a 100-mesh sieve is taken. 30 grams of sieved and added to the flask, remove the oxide layer of sodium metal with a wallpaper knife, cut into small pieces, add 12 grams of sodium metal to the flask, turn on nitrogen protection, heat with an oil bath, set the temperature at 240°C, and stir at a speed of 1000 revolutions, observe the internal state of the flask, the internal material changes from a loose type to an alloy state and then maintains the temperature for 0.5 hours. Cool down to 40°C and add toluene for protection. The catalyst was used to carry out the synthesis test of isobutylbenzene, and the conversion rate was determined to be 45.2%.

Embodiment 2

[0021] Example 2: Put potassium carbonate in a stainless steel tray, place it in a muffle furnace to heat up and dry, control the temperature at 250°C, and dry for 1 hour. After drying, grind it with a pulverizer, sieve it with a sieve, and take a 100-mesh sieve. Sieve 30 grams of sodium metal, add it to the flask, turn on the nitrogen protection, remove the oxide layer of the metal sodium with a wallpaper knife, cut it into small pieces, add 9 grams of metal sodium to the flask, heat with an oil bath, set the temperature at 220 ° C, and stir at a speed of 1100 revolutions, observe the internal state of the flask, the internal material changes from a loose type to an alloy state and then maintains the temperature for 0.5 hours. Cool down to 45°C and add toluene for protection. The catalyst was used to carry out the synthesis test of isobutylbenzene, and the conversion rate was determined to be 43.5%.

Embodiment 3

[0022] Embodiment 3: Embodiment 2: Potassium carbonate is filled in the stainless steel tray, is placed in the muffle furnace and is heated and dried, and the temperature is controlled at 250 ℃, and the drying time is 1 hour. After drying, pulverize with a pulverizer, sieve with a sieve, and take Sieve 30 grams of 150-mesh sieve, add to the flask, remove the oxide layer of metal sodium with a wallpaper knife, cut into small pieces, add 12 grams of metal sodium to the flask, turn on nitrogen protection, heat with an oil bath, set the temperature to 240 ℃, the stirring speed is 1300 rpm, and the internal state of the flask is observed. The internal material changes from a loose type to an alloy state and then maintains the temperature for 0.5 hours. Cool down to 40°C and add toluene for protection. The catalyst was used to carry out the synthesis test of isobutylbenzene, and the conversion rate was determined to be 52.1%.

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Abstract

The invention belongs to the field of pharmaceutical chemicals, and particularly relates to a preparation process of a novel catalyst for an isobutylbenzene synthesis process. Isobutylbenzene (IBB) is a main intermediate for synthesizing a human medicine ibuprofen which is used for diminishing inflammation, relieving fever and easing pain. A main synthesis method of the isobutylbenzene is an alkylation method taking methylbenzene and propylene as raw materials, and isobutylbenzene is generated through a side chain alkylation reaction in the presence of a basic catalyst. Alkali metal needs to be used as a catalyst for the side chain alkylation reaction, at present, metal potassium catalysts or potassium-sodium alloy catalysts are usually used at home and abroad, and the production cost is greatly reduced and the economic benefit is improved by using cheaper metal sodium.The present invention uses metallic sodium and potassium carbonate to make the novel catalyst, and the catalyst is used for synthetic reaction of isobutylbenzene products.

Description

technical field [0001] The invention belongs to the field of medicine and chemical industry, and in particular relates to a preparation process of an alkali metal catalyst in an isobutylbenzene synthesis process. Background technique [0002] Isobutylbenzene (IBB) is the main intermediate in the synthesis of ibuprofen, an anti-inflammatory, antipyretic and analgesic human drug. Since ibuprofen was put into the market in 1969, it is still very popular, so the demand for isobutylbenzene at home and abroad is increasing day by day. The main synthesis method of isobutylbenzene is the alkylation method of toluene and propylene as raw materials, and the side chain alkylation reaction occurs in the presence of a basic catalyst to generate isobutylbenzene. The side chain alkylation reaction requires the use of alkali metals as catalysts. At present, metal potassium catalysts or potassium-sodium alloy catalysts are widely used at home and abroad, but metal potassium is expensive, wh...

Claims

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Application Information

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IPC IPC(8): B01J27/236
CPCB01J27/236
Inventor 王凯广孙淑正尹进华
Owner 山东新华万博化工有限公司
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