Polypyrrole chitosan drug-loaded fibrous membrane for artificial nerve conduit and preparation method of polypyrrole chitosan drug-loading fibrous membrane

A polypyrrole chitosan, artificial nerve technology, applied in the manufacture of rayon, chemical characteristics of fibers, single-component polyester rayon, etc., can solve the problems of poor electrical conductivity, low drug-carrying biological activity, etc. Fast production, good biocompatibility, accelerated results

Active Publication Date: 2021-06-15
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a preparation method of polypyrrole chitosan drug-loaded fiber membrane for artificial nerve catheters in view of the shortcomings of poor electrical conductivity and low drug-loaded biological activity of degradable high-molecular polymer materials in the prior art , the fibrous membrane prepared by this method can release drugs continuously and has good electrical conductivity

Method used

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  • Polypyrrole chitosan drug-loaded fibrous membrane for artificial nerve conduit and preparation method of polypyrrole chitosan drug-loading fibrous membrane
  • Polypyrrole chitosan drug-loaded fibrous membrane for artificial nerve conduit and preparation method of polypyrrole chitosan drug-loading fibrous membrane
  • Polypyrrole chitosan drug-loaded fibrous membrane for artificial nerve conduit and preparation method of polypyrrole chitosan drug-loading fibrous membrane

Examples

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Embodiment 1

[0028] (1) Weigh 50mg of chitosan powder and dissolve it in 50mL of 1% (v / v) acetic acid solution, stir overnight at 500rpm to fully dissolve chitosan, adjust the pH to 5.0 with NaOH solution and add 50mg of bovine serum albumin BSA (drug model protein), 100rpm stirring makes it dissolve completely, obtains the mixed solution of BSA and chitosan.

[0029](2) Prepare 1.0mg / mL sodium tripolyphosphate (TPP) solution, use a rubber dropper to draw a certain amount of TPP solution and add it dropwise at a constant speed to the mixed solution of BSA and chitosan in (1) stirred at 500rpm , the mass ratio of the added TPP to chitosan was 1:4, after the dropwise addition was completed, the stirring was continued to obtain a suspension of chitosan microspheres loaded with BSA.

[0030] (3) The suspension in (2) is transferred to a centrifuge tube, and after centrifugation, the precipitated layer is freeze-dried with a freeze dryer to obtain dry chitosan microspheres loaded with BSA.

[...

Embodiment 2

[0035] The steps in embodiment 2 are the same as those in embodiment 1, except that BSA is not added in step (1), and in step (4), 0.04 g of ibuprofen powder is added to the spinning solution and stirred evenly.

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Abstract

The invention discloses a polypyrrole chitosan drug-loaded fibrous membrane for an artificial nerve conduit and a preparation method of the polypyrrole chitosan drug-loaded fibrous membrane, and belongs to the field of tissue engineering. The method includes the following steps: adding chitosan drug-loaded microspheres or ibuprofen into a high-molecular polymer solution to obtain a drug-loaded spinning solution, carrying out electrostatic spinning on the drug-loaded spinning solution to obtain a drug-loaded fiber membrane, and coating the surface of the drug-loaded fiber membrane with a polypyrrole coating to obtain the polypyrrole chitosan drug-loaded fiber membrane. According to the method, a drug is loaded on the chitosan microspheres and then encapsulated in high-molecular polymer fibers, so that bioactive molecules such as nerve growth factors are protected, slow release of the drug is beneficial to nerve restoration; the high-molecular polymer has good biocompatibility and meets mechanical requirements of the nerve conduit; and the polypyrrole is coated, so that the fibers have electrical conductivity, meets requirements of physiological current of a human body, and is beneficial to accelerating neural restoration.

Description

technical field [0001] The invention belongs to the field of tissue engineering, and relates to a polypyrrole chitosan drug-loaded fiber membrane used for artificial nerve guides and a preparation method thereof. Background technique [0002] Tissue engineering aims to develop replacements for functionally impaired tissues and organs. Before transplantation, the cells are usually seeded on a biomaterial scaffold that mimics the extracellular matrix and provides the cells with information important for tissue development. Tissue engineering is an emerging interdisciplinary field that applies principles of biology and engineering to develop biological substitutes that restore, maintain, or improve tissue function. It usually requires a scaffold to provide transitional three-dimensional support for cell migration, attachment, and proliferation, and to provide a vehicle for the delivery of biochemical factors. Scaffolds should also provide mechanical and biological influences ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/728D04H1/435D01F1/10D01F6/92
CPCD04H1/728D04H1/435D01F1/10D01F6/92D10B2509/00D10B2401/12
Inventor 李媛喻潇凌张甜
Owner WUHAN UNIV OF TECH
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