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Method for efficiently preparing raw material medicine icodextrin

A technology for testing dextrin and raw materials, which is applied in the field of high-efficiency preparation of raw material icodextrin, which can solve problems such as complex process, high cost, and unsuitability for industrial production, and achieve optimized ultrafiltration process, mild reaction, and reduction of insoluble starch particles the effect produced

Active Publication Date: 2021-06-18
ZIBO QIANHUI BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The process of this patent is complicated, the cost is high, and it is not suitable for industrialized production

Method used

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  • Method for efficiently preparing raw material medicine icodextrin
  • Method for efficiently preparing raw material medicine icodextrin
  • Method for efficiently preparing raw material medicine icodextrin

Examples

Experimental program
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Embodiment 1

[0039] 1) Sizing and liquefaction: mix 100g of starch, 300g of water and 1-2g of polystyrene microspheres at room temperature for slurrying, place in a water bath at 100°C and stir for gelatinization for 20 minutes;

[0040] 2) Lower the gelatinized starch to 90°C, slowly drop 100g of hydrochloric acid solution with a mass concentration of 0.27% into the reaction solution, and control the dropwise addition within 30min; heat preservation reaction for 2h;

[0041] 3) Adjust the pH to between 3 and 4, terminate the reaction, add 0.3g of activated carbon and 0.015g of chitosan to decolorize at room temperature, use 100KDa and 5000Da ultrafiltration membranes for molecular weight screening respectively, and control the ultrafiltration pressure to 300KPa, 5000Da for ultrafiltration When the polarimeter tracks the value of the optical rotation of the discharged liquid to 0.200, the ultrafiltration is completed, and the liquid is spray-dried to obtain the finished product. Yield 67.4...

Embodiment 2

[0044] 1) Sizing and liquefaction: Mix 100g of starch, 800g of water and 1-2g of insoluble cellulose particles at room temperature for slurrying, place in a water bath at 95°C and stir for 30 minutes to gelatinize.

[0045] 2) Control the gelatinized starch at 95°C, slowly drop 100 g of nitric acid solution with a mass concentration of 0.4% into the reaction solution, and control the dropping within 40 minutes; keep warm for 3 hours;

[0046] 3) Adjust the pH to between 3 and 4, terminate the reaction, add 0.55g of activated carbon, 0.033g of chitosan to decolorize at room temperature, use 100KDa and 5000Da ultrafiltration membranes for molecular weight screening, ultrafiltration pressure 300KPa, 5000Da ultrafiltration process with optical rotation The ultrafiltration is completed when the optical rotation value of the effluent liquid is tracked by the instrument to 0.350, and the material liquid is spray-dried to obtain the finished product. Yield 68.2% (starch dry product).

...

Embodiment 3

[0049] 1) Sizing and liquefaction: Mix 100g of starch, 200g of water and 1-2g of poly(N-isopropylacrylamide) microgel particles at room temperature for slurrying, place in a 95°C water bath and stir for gelatinization for 50min;

[0050] 2) Lower the gelatinized starch to 85°C, slowly drop 100 g of sulfuric acid solution with a mass concentration of 0.4% into the reaction solution, and control the addition within 30 minutes; heat preservation reaction for 2.5 hours;

[0051] 3) Adjust the pH to between 3 and 4, terminate the reaction, add 0.36g of activated carbon, 0.025g of chitosan to decolorize at room temperature, use 100KDa and 5000Da ultrafiltration membranes for molecular weight screening, ultrafiltration pressure 400KPa, 5000Da ultrafiltration process with optical rotation The ultrafiltration is completed when the optical rotation value of the effluent liquid is tracked by the instrument to 0.250, and the material liquid is spray-dried to obtain the finished product. Y...

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Abstract

A method for efficiently preparing raw material medicine icodextrin belongs to the technical field of preparation of medicine raw materials, is characterized by sequentially comprising the procedures of gelatinization, acidolysis, decoloration and ultrafiltration, and is characterized in that in the decoloration procedure, activated carbon and chitosan are used for decoloration once or twice at the pH value of 3-4, wherein the total addition amount of the activated carbon and the chitosan is 0.5-1g / L, and the addition amount of the chitosan is 0.05-0.1 time of the weight of the activated carbon. According to the method, decolorization and ultrafiltration processes are optimized, and gelatinization and acidolysis processes are adjusted, so that the reaction efficiency is improved, the conversion rate is increased, and the molecular weight distribution of a target product is more concentrated.

Description

technical field [0001] The invention relates to a method for efficiently preparing raw material medicine icodextrin, which belongs to the technical field of medicine raw material preparation. Background technique [0002] As the main active ingredient of peritoneal dialysis solution, icodextrin is a water-soluble glucose polymer linked by starch through α-(1-4) and less than 10% α(1-6) glycosidic bonds, with a weight average molecular weight of 13000 -19000Da, the number average molecular weight is 5000-6500Da. [0003] The icodextrin peritoneal dialysis solution (Extraneal) produced by Baxter was approved for marketing in Japan in 2003. As a glucose polymer, icodextrin can be degraded into small molecule polymers by starch acid hydrolysis, lye solution or enzymatic hydrolysis, and then screened by molecular weight to obtain icodextrin. [0004] The Chinese patent with the publication number CN103467608A discloses a kind of icodextrin and its preparation method. The prepar...

Claims

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Application Information

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IPC IPC(8): C08B30/18
CPCC08B30/18
Inventor 王哲许维成崔丽艳刘涛
Owner ZIBO QIANHUI BIOTECH
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