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Novel diaryl nonane II and I free-radical inhibitor in Saxifraga tangutica, separation and preparation process for novel diaryl nonane II and I free-radical inhibitor and application of novel diaryl nonane II and I free-radical inhibitor

A kind of technology of diarylnonane and tangut tiger ear, which is applied in the field of separation of diarylnonane radical inhibitors

Active Publication Date: 2021-07-06
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The relevant research of this research group has applied for a national invention patent (application number: 202010041021.3), which describes the separation, preparation and application of six galloyl-based natural free radical scavengers with known structures in Saxifrage tangutica, and up to now There are no literature or patent reports involving new diarylnonane free radical inhibitors

Method used

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  • Novel diaryl nonane II and I free-radical inhibitor in Saxifraga tangutica, separation and preparation process for novel diaryl nonane II and I free-radical inhibitor and application of novel diaryl nonane II and I free-radical inhibitor
  • Novel diaryl nonane II and I free-radical inhibitor in Saxifraga tangutica, separation and preparation process for novel diaryl nonane II and I free-radical inhibitor and application of novel diaryl nonane II and I free-radical inhibitor
  • Novel diaryl nonane II and I free-radical inhibitor in Saxifraga tangutica, separation and preparation process for novel diaryl nonane II and I free-radical inhibitor and application of novel diaryl nonane II and I free-radical inhibitor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] The separation and preparation process of the new diarylnonane class II and I free radical inhibitors in Saxifraga tangutica, specifically includes the following steps:

[0063] Step 1, extraction: dry 500g of saxifrage whole herb in the shade, coarsely crush it and extract it with methanol at a material-to-liquid ratio of 1g: 5mL, extract 4 times at room temperature for 2 hours each time, filter and combine the filtrates, namely filtrate A, The filtrate A is mixed according to the amount of polyamide: the amount of saxifrage tangutica medicinal material = 1:5 and then dried under reduced pressure. The conditions for drying under reduced pressure are: vacuum degree 50mbar, temperature 40°C, to obtain saxifrage tangutatus Grass extract mixed sample 160.2g;

[0064] Step 2, coarse separation of microporous resin column: sample mixed with saxifrage extract of Tangutia tanguticae, the sample is separated by medium-pressure chromatography equipped with microporous resin, det...

Embodiment 2

[0072] The separation and preparation process of the new diarylnonane class II and I free radical inhibitors in Saxifraga tangutica, specifically includes the following steps:

[0073] Step 1, extraction: dry 1000g of saxifrage whole herb in the shade, coarsely crush it and extract it according to the ratio of solid to liquid: 1g: 100mL of methanol, extract twice at room temperature, each time for 4h, filter and combine the filtrates, that is, filtrate A, The filtrate A is mixed according to the amount of polyamide: the amount of saxifrage tangutica medicinal material = 1:5 and then dried under reduced pressure, wherein the conditions for drying under reduced pressure are: vacuum degree 250mbar, temperature 60°C, to obtain saxifrage tangutatus Grass extract mixed sample 319.3g;

[0074] Step 2, coarse separation of microporous resin column: sample mixed with saxifrage extract of Tangutia tanguticae, the sample is separated by medium-pressure chromatography equipped with microp...

Embodiment 3

[0082] The separation and preparation process of the new diarylnonane class II and I free radical inhibitors in Saxifraga tangutica, specifically includes the following steps:

[0083] Step 1, extraction: dry 1200g of saxifrage whole herb in the shade, coarsely crush it and extract it according to the ratio of solid to liquid: 1g: 50mL of methanol, extract at room temperature 3 times, each time for 3h, filter and combine the filtrates, that is, filtrate A, The filtrate A is mixed according to the amount of polyamide: the amount of saxifrage tangutica medicinal material = 1:5 and then dried under reduced pressure, wherein the conditions for drying under reduced pressure are: vacuum degree 150mbar, temperature 50°C, to obtain saxifrage tangutatus Grass extract mixed sample 363.7g;

[0084] Step 2, coarse separation of microporous resin column: sample mixed with saxifrage extract of Tangutia tanguticae, the sample is separated by medium-pressure chromatography equipped with micro...

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Abstract

The invention discloses a novel diaryl nonane II and I free-radical inhibitor in Saxifraga tangutica, a separation and preparation process for the novel diaryl nonane II and I free-radical inhibitor and application of the novel diaryl nonane II and I free-radical inhibitor. The specific process comprises the steps of extracting, microporous-resin-column rough separating, online free-radical inhibitor component screening, out-phase medium-pressure chromatographic column separating, online free-radical inhibitor screening, and high-pressure preparative column preparing. The prepared free-radical inhibitor can be applied to preparation of free-radical inhibiting drugs or health-care foods and is specifically prepared into all classes of pharmaceutical preparations or health-care foods as an effective ingredient according to any support acceptable in pharmacy or food science. In the process, an extraction solvent, a microporous resin column, and a solvent and a separating material which are employed by the out-phase medium-pressure chromatographic column separating all can be recycled; and the source of raw materials is wide, processing steps such as methanol room-temperature cold-soaking extraction, microporous-resin-column rough separating and the out-phase medium-pressure chromatographic column separating all can achieve formalized operation, and the condition that the purity of a product is higher than 95% can be guaranteed by high-pressure preparation chromatographic separation.

Description

technical field [0001] The invention relates to the technical field of separation of new diarylnonane free radical inhibitors in saxifrage tangutica, in particular to new diarylnonane class II and I free radical inhibitors in saxifrage tangutica and its Separation preparation process and application. Background technique [0002] Saxifraga tangutica Engl., also known as Ganqing saxifrage, is an annual evergreen herb of Saxifragaceae (Saxifragaceae) genus Saxifraga. Tibetan medicine name: "Songjidi", traditional Chinese medicine It is called "Dieda" in Chinese, and it is mainly distributed in Qinghai, Gansu, Tibet, Sichuan, and Bhutan and Kashmir under the coniferous forest shrubs at an altitude of 2900-4900 meters. Tangut saxifrage is a commonly used Tibetan medicine, and the whole herb can be used as medicine. "Chinese Medicine Cihai" records: its nature and taste are slightly bitter, pungent, and cold. Main effects: clearing the liver and gallbladder, invigorating the sp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/18C07H15/24C07H1/08A61P39/06A23L33/105
CPCC07H15/18C07H15/24C07H1/08A61P39/06A23L33/105A23V2002/00A23V2200/30A23V2250/2132
Inventor 党军王启兰陶燕铎
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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