Synthesis method of 2,2,2',4',5'-pentachloroacetophenone

Abstract

The invention provides a synthesis method of 2,2,2',4',5'-pentachloroacetophenone. Raw materials comprise, by weight, 52-75 parts of 1,2,4-trichlorobenzene, 40-62 parts of dichloroacetyl chloride, 32-58 parts of a catalyst and 28-50 parts of water. A conventional temperature curve is broken, temperature change is utilized, and the catalyst is added at different time periods according to the proportion, so that the utilization rate of the catalyst is effectively improved, and the reaction degree is promoted to be more thorough; meanwhile, the catalyst adopts a carrier medium-Lewis acid compound, the carrier medium is prepared by utilizing the activity of microorganisms, and the catalyst is supported on a porous carrier, so that the activity of the catalyst is increased, the yield and the purity are improved, and the reaction rate and the reaction degree are prevented from being slowed down due to catalyst deposition in the reaction process; in addition, after the reaction is finished, an organic layer is washed and filtered by a high-efficiency filter membrane to further remove impurities, so that the purity of the product is effectively improved.

Description

technical field [0001] The invention belongs to the field of organic chemical synthesis, in particular to a synthetic method of 2,2,2',4',5'-pentachloroacetophenone. Background technique [0002] 2,2,2',4',5'-Pentachloroacetophenone is an important fine chemical intermediate, a raw material for many medicines and pesticides, and is widely used in medicine, pesticides and other fields. [0003] In the prior art, the synthesis of 2,2,2',4',5'-pentachloroacetophenone is mostly based on the catalysis of dichloroacetyl chloride and 1,2,4-trichlorobenzene in Lewis acid aluminum chloride The acetylation reaction is carried out under the following conditions, and the yield is generally about 80% when the yield is good. The disadvantages of this method are inevitable, such as the yield needs to be improved, the amount of Lewis acid catalyst used remains high, and the purification means after the reaction is over A series of problems such as poor product purity lead to a series of pr...

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Problems solved by technology

[0003] In the prior art, the synthesis of 2,2,2',4',5'-pentachloroacetophenone is mostly based on the catalysis of dichloroacetyl chloride and 1,2,4-trichlorobenzene in Lewis acid aluminum chloride The acetylation reaction is carried out under the following conditions, and the yield is generally about 80% when the yield is good. The disadvantages of this method are inevitable, such as the yield needs to be improved, the amount of Lewis acid catalyst used remains high, and the purification means after the reaction is over A series of problems such as poor product purity lead to a series of problems, which not only brings huge pressure to the industrialization of enterprises, but also reflects the problem of excessive disposal of residual materials, which is a big problem for environmental protection.

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