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Traditional Chinese medicine composition for treating restenosis or angina pectoris after percutaneous coronary intervention and application thereof

A composition and a technology for restenosis, applied in the field of traditional Chinese medicine, can solve the problems of lack of specific methods in western medicine, angina pectoris recurrence, thrombosis and other problems, and achieve the effects of reducing the incidence of restenosis, enhancing myocardial contractility and stabilizing blood pressure

Inactive Publication Date: 2021-07-23
GUANGANMEN HOSPITAL CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although the clinical application of PCI technology is becoming more and more mature and advanced, and the acceptance rate of patients is getting higher and higher, the adverse consequences after PCI are also worthy of vigilance. According to statistics, patients after PCI have chest pain, anxiety, restenosis, Complications such as thrombosis, recurrent angina, recurrent non-fatal myocardial infarction, and bleeding due to the antiplatelet drug clopidogrel
In the treatment of complications after PCI, Western medicine lacks effective and specific methods

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0133] A traditional Chinese medicine composition for treating restenosis or angina pectoris after coronary heart disease intervention, comprising the following raw materials: Salvia miltiorrhiza 15g, Trichosanthes mellifera 15g, Allium scallions 15g, Pinellia fragrans 9g, Guizhi 6g, Radix paeoniae Rubra 9g, Rhizoma Chuanxiong 6g, Angelica 10g, Scrophulariaceae 15g, Silkworm 6g, Turmeric 6g, Coptis 5g, Licorice 6g.

[0134] Adopt conventional water decoction method, decoct and take decoction.

Embodiment 2

[0136] A traditional Chinese medicine composition for treating restenosis or angina pectoris after coronary heart disease intervention, comprising the following raw materials: Salvia miltiorrhiza 12g, Trichosanthes mellifera 10g, Allium scallions 9g, Pinellia fragrans 6g, Guizhi 9g, Radix paeoniae Rubra 12g, Rhizoma Chuanxiong 9g, Angelica 10g, Scrophulariaceae 12g, silkworm 8g, turmeric 9g, licorice 9g.

[0137] Add water to decoct 3 times, add 10 times the amount of water for the first time and decoct for 1.5 hours, then add 6 times the amount of water and decoct for 1 hour, combine the filtrate, add appropriate amount of dextrin, concentrate under reduced pressure to form a paste, add starch to make granules agent.

Embodiment 3

[0139] A traditional Chinese medicine composition for treating restenosis or angina pectoris after coronary heart disease intervention, comprising the following raw materials: Salvia miltiorrhiza 12g, Trichosanthes mellifera 10g, Allium scallions 9g, Pinellia fragrans 6g, Guizhi 9g, Radix paeoniae Rubra 12g, Rhizoma Chuanxiong 9g, Angelica 10g, Scrophulariaceae 12g, Silkworm 8g, Turmeric 9g, Licorice 9g, Coptis 3g.

[0140] Add water to decoct twice, each time add 8 times the amount of water to decoct for 1 hour, combine the filtrate, add appropriate amount of dextrin, concentrate under reduced pressure to form a paste, add conventional auxiliary materials to make tablets.

[0141] The traditional Chinese medicine composition prepared in each of the above examples has significant curative effects in improving myocardial ischemia, improving atherosclerosis, stabilizing blood pressure, enhancing myocardial contractility, and reversing cardiac remodeling.

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition for treating restenosis or angina pectoris after percutaneous coronary intervention. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-15 parts of salvia miltiorrhiza, 9-15 parts of trichosanthes kirilowii maxim, 5-10 parts of allium macrostemon, 3-9 parts of rhizoma pinellinae praeparata, 3-10 parts of cassia twig, 6-15 parts of radix paeoniae rubra, 3-10 parts of ligusticum wallichii, 6-12 parts of angelica sinensis, 9-15 parts of radix scrophulariae, 5-10 parts of stiff silkworm, 6-10 parts of turmeric and 2-10 parts of liquorice. The traditional Chinese medicine composition can be used for effectively treating restenosis or angina pectoris after the percutaneous coronary intervention. The invention further discloses application of the traditional Chinese medicine composition.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine. More specifically, it relates to a traditional Chinese medicine composition for treating restenosis or angina pectoris after interventional coronary heart disease and its application. Background technique [0002] Coronary atherosclerotic heart disease (CHD) refers to the stenosis or blockage of coronary artery atherosclerosis, or (and) myocardial ischemia and hypoxia caused by functional changes (spasm) of coronary arteries or Heart disease caused by necrosis, referred to as coronary heart disease, also known as ischemic heart disease. Clinically, coronary heart disease often leads to angina pectoris, myocardial infarction, ventricular aneurysm, and even heart rupture, which brings huge risks to the quality of life and life safety of patients. According to the summary of "China Cardiovascular Disease Report 2018", in 2016, the mortality rate of cardiovascular disease in Ch...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P9/10A61K35/64
CPCA61K35/64A61K36/232A61K36/236A61K36/268A61K36/428A61K36/481A61K36/484A61K36/537A61K36/54A61K36/65A61K36/71A61K36/718A61K36/752A61K36/808A61K36/8888A61K36/8962A61K36/9066A61P9/10A61K2300/00
Inventor 李军陈恒文谭雨晴查玉玲高健吴晓博邵祯
Owner GUANGANMEN HOSPITAL CHINA ACAD OF CHINESE MEDICAL SCI
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