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Preparation method and application of <68>Ga-GaCl3 solution with high radioactive nuclear purity

A 68ga-gacl3, high radioactivity technology, applied in the field of radiology, can solve complex, expensive process, slow and other problems, achieve the effect of improving accuracy, promoting research and wide application

Pending Publication Date: 2021-07-23
GUANGDONG HUIXUAN PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although this method can achieve high yields, the process is a slow, complex and expensive process

Method used

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  • Preparation method and application of &lt;68&gt;Ga-GaCl3 solution with high radioactive nuclear purity

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Embodiment 1

[0024] This embodiment provides a high radioactive core purity 68 GA-GaCl 3 Preparation method of solution, pass: 68 Zn-Zn (NO 3 ) 2 The solution is a target, using a proton bombardment 68 Zn-Zn (NO3 ) 2 Liquid target 68 Zn (p, n) 68 GA nuclear reaction is obtained. Specifically, the following steps:

[0025] (1) adopting 68 Zn-Zn (NO 3 ) 2 Solution filled the target, using proton bombardment 68 Zn-Zn (NO 3 ) 2 Liquid target, bombardment beam flow is 40μA, accelerated energy is 15 MeV, and the bombardment time is 1 h. through 68 Zn (p, n) 68 GA nuclear reaction 68 GA-GA (NO 3 ) 3 / 68 Zn-Zn (NO 3 ) 2 Hybrid;

[0026] (2) Adopt a strong cation exchange column to obtain steps 68 GA-GA (NO 3 ) 3 / 68 Zn-Zn (NO 3 ) 2 The mixture was purified, and the selected cation exchange column was used as a matrix with a styrene-divinylbenzene polymer, bonded benzenesulfonic acid as a fixed phase, with hydrogen ions as exchange equilibrium ions. The aqueous 0.84 m aqueous hydrobromate aqueous sol...

Embodiment 2

[0028] This embodiment provides a high radioactive core purity 68 GA-GACL 3 Preparation method of solution, pass: 68 Zn-Zn (NO 3 ) 2 The solution is a target, using a proton bombardment 68 Zn-Zn (NO 3 ) 2 Liquid target 68 Zn (p, n) 68 GA nuclear reaction is obtained. Specifically, the following steps:

[0029] (1) adopting 68 Zn-Zn (NO 3 ) 2 Solution filled the target, using proton bombardment 68 Zn-Zn (NO 3 ) 2 The liquid target, the bombardment beam is 35μA, the acceleration energy is 14 MeV, and the bombardment time is 70 min. through 68 Zn (p, n) 68 GA nuclear reaction 68 GA-GA (NO 3 ) 3 / 68 Zn-Zn (NO 3 ) 2 Hybrid;

[0030] (2) Adopt a strong cation exchange column to obtain steps 68 GA-GA (NO 3 ) 3 / 68 Zn-Zn (NO 3 ) 2 The mixture was purified, and the selected cation exchange column was used as a matrix with a styrene-divinylbenzene polymer, bonded benzenesulfonic acid as a fixed phase, with hydrogen ions as exchange equilibrium ions. The aqueous 0.84 m aqueous hydrobromate...

Embodiment 3

[0032] This embodiment provides a high radioactive core purity 68 GA-GACL 3 Preparation method of solution, pass: 68 Zn-Zn (NO 3 ) 2 The solution is a target, using a proton bombardment 68 Zn-Zn (NO 3 ) 2 Liquid target 68 Zn (p, n) 68 GA nuclear reaction is obtained. Specifically, the following steps:

[0033] (1) adopting 68 Zn-Zn (NO 3 ) 2 Solution filled the target, using proton bombardment 68 Zn-Zn (NO 3 ) 2 Liquid target, bombardment beam flow is 45μA, accelerated energy is 16 MeV, and the bombardment time is 50 min. through 68 Zn (p, n) 68 GA nuclear reaction 68 GA-GA (NO 3 ) 3 / 68 Zn-Zn (NO 3 ) 2 Hybrid;

[0034] (2) Adopt a strong cation exchange column to obtain steps 68 GA-GA (NO 3 ) 3 / 68 Zn-Zn (NO 3 ) 2 The mixture was purified, and the selected cation exchange column was used as a matrix with a styrene-divinylbenzene polymer, bonded benzenesulfonic acid as a fixed phase, with hydrogen ions as exchange equilibrium ions. The aqueous solution of 0.5 m aqueous hydrobrom...

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Abstract

The invention provides a preparation method and application of a <68>Ga-GaCl3 solution with high radioactive nuclear purity. The preparation method comprises the following steps of by taking a <68>Zn-Zn (NO3) 2 solution as a target material, bombarding a <68>Zn-Zn (NO3) 2 liquid target by using protons, and carrying out a <68>Zn (p, n) <68>Ga nuclear reaction. The positron nuclide <68> Ga is produced by bombarding the <68> Zn-Zn (NO3) 2 liquid target by protons, the <68> GaCl3 solution which can be used for positron radiopharmaceutical production marking is obtained after separation and purification, the chemical indexes of the <68> GaCl3 solution are consistent with those of commercially obtained <68> GaCl3 solution, and therefore a basis is provided for formulating the quality standard of <68> Ga radiopharmaceuticals in China. In addition, the radioactive marker can be directly used for marking small molecule drugs such as PSMA, FAPI and BBN and marking polypeptide tracers, and research and wide application of <68> Ga marked radioactive drugs in Guangdong are promoted.

Description

Technical field [0001] The present invention relates to the field of radioactive medicine, and specific relatable 68 GA-GaCl 3 Preparation method and application of solution. Background technique [0002] Positive electron emission computer fault (PET) imaging has been widely used in the clinical diagnosis and evaluation of diseases. About the positive electronic melter 68 The research of GA can be traced back to the late 1950s, early development slowly; with the advancement of technology, gradually increased research after 2000, and burst growth in 2010. Currently 68 The application of GA in PET imaging is second only 18 F. 68 GA 68 GE / 68 GA generator production. 68 GE / 68 GA generator 68 The half-life of the GE is 270.8d, prepared 68 The physical half-life of GA is 67.71 min, and the positive electron decay rate in the decay process accounts for 89%, EMAX is 1.92MeV, and the remaining 11% is electronically captured, and pharmacokinetics suitable for marking small molecule dr...

Claims

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Application Information

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IPC IPC(8): A61K51/04A61K51/12C01G15/00A61K103/00
CPCA61K51/0482A61K51/121C01G15/00
Inventor 李桂铤毛献金陈海涛陆天鸿王明芳黄文涛
Owner GUANGDONG HUIXUAN PHARMA TECH
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