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Preparation and Application of a Biocompatibility Coating for Improving the Surface of Medical Zinc/Zinc Alloy

A biocompatible, zinc alloy technology, applied in metal material coating technology, coating, medical science and other directions, can solve the problem of poor osteogenic performance and the explosive release of harmful ions, etc., to meet clinical needs, the process is simple, good adhesion

Active Publication Date: 2021-12-03
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to provide a method for improving the preparation and application of a medical zinc / zinc alloy surface biocompatibility coating for the problems of poor early osteogenic performance of zinc / zinc alloy and explosive release of harmful ions.

Method used

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  • Preparation and Application of a Biocompatibility Coating for Improving the Surface of Medical Zinc/Zinc Alloy
  • Preparation and Application of a Biocompatibility Coating for Improving the Surface of Medical Zinc/Zinc Alloy

Examples

Experimental program
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Effect test

Embodiment 1

[0035]Prepare a silicon-doped bioactive calcium-phosphorus coating on the surface of the Zn-Mg alloy. The Zn-Mg alloy rod is made into a Ф10×2mm sample by wire cutting. Grinding with silicon carbide sandpaper, followed by ultrasonic cleaning with acetone, alcohol and deionized water for 10 minutes to remove impurities and oil stains on the surface, and air drying at room temperature for later use. Prepare a zinc phosphate solution with a concentration of 0.05mol / L zinc nitrate and 0.2mol / L phosphoric acid, adjust the pH of the obtained conversion solution to 3 with NaOH, and soak the cleaned zinc alloy in the zinc phosphate conversion solution for 1 hour at room temperature Then take it out and wash it with pure water and blow dry. Then, configure 0.5mol / L calcium chloride and 0.001mol / L sodium silicate solution, put the pretreated sample into the solution, take it out after 8 hours in a constant temperature water bath at 90°C, rinse it with pure water, and dry it to get Zn -...

Embodiment 2

[0037] A strontium-doped bioactive calcium-phosphorus coating was prepared on the surface of the Zn-Sr alloy. After the sample was polished, it was ultrasonically cleaned with acetone, alcohol, and deionized water for 10 minutes to remove impurities and oil on the surface, and air-dried at room temperature for later use. Prepare a zinc phosphate solution with a concentration of 0.07mol / L zinc nitrate and 0.15mol / L phosphoric acid, and use NaOH to adjust the pH of the obtained conversion solution to 2.5, and soak the cleaned zinc alloy in the zinc phosphate conversion solution for 1 hour at room temperature Then take it out and wash it with pure water and blow dry. Then, configure 0.5mol / L calcium chloride and 0.005mol / L strontium nitrate solution, put the pretreated sample into the solution, take it out after 4 hours in a constant temperature water bath at 90°C, rinse it with pure water, and then dry it to get Zn- Strontium-doped bioactive calcium-phosphorus coating prepared o...

Embodiment 3

[0039] A copper-doped bioactive calcium-phosphorus coating was prepared on the surface of the Zn alloy. After the sample was polished, it was ultrasonically cleaned with acetone, alcohol, and deionized water for 10 minutes to remove impurities and oil on the surface, and air-dried at room temperature for later use. Prepare a zinc phosphate solution with a concentration of 0.10mol / L zinc nitrate and 0.25mol / L phosphoric acid, and use NaOH to adjust the pH of the obtained conversion solution to 2, and soak the cleaned zinc alloy in the zinc phosphate conversion solution for 50 minutes at room temperature Then take it out and wash it with pure water and blow dry. Then, configure 0.4mol / L calcium chloride and 0.4mol / L copper chloride solution, put the pretreated sample into the solution, take it out after 10 hours in a constant temperature water bath at 80°C, rinse it with pure water, and dry it to obtain Zn -Copper-doped bioactive calcium-phosphorus coating prepared on Li alloy s...

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Abstract

The invention discloses the preparation and application of a coating for improving the biocompatibility of the zinc / zinc alloy surface. The coating includes a phosphate conversion coating, a calcium-phosphorus coating and a doping active Elemental calcium-phosphorus coating; during preparation, the zinc / zinc alloy is soaked in the conversion solution composed of zinc nitrate and phosphoric acid at room temperature to form a zinc phosphate conversion coating; a layer of calcium can also be deposited on the surface of the zinc phosphate conversion coating in a water bath Phosphorus coatings, and calcium-phosphorus coatings doped with active elements can be prepared according to clinical needs. The coating prepared by the invention has a simple and easy operation process, strong binding force between the coating and the substrate, can improve the biocompatibility of the zinc / zinc alloy and regulate ion release, and the doping of active elements can obtain the same Natural apatite is a more similar material, and endows the active elements of the coating with unique biological characteristics, making it have better osteoinductive regenerative functions.

Description

technical field [0001] The invention belongs to the technical field of preparation of biomedical materials, in particular to the preparation and application of a biocompatibility coating for improving the surface of medical zinc / zinc alloy. Background technique [0002] With the development of medicine and material science, it is a trend of clinical medicine to use some materials to repair and replace damaged tissues and organs. Biomedical materials currently used in clinical practice mainly include biomedical metal materials, inorganic materials, polymer materials, composite materials, and bionic materials. Compared with other materials, biomedical metal materials have excellent mechanical properties, so they are often used in the replacement and repair of load-bearing and hard tissues. Commonly used biomedical metal materials such as: 316L, 317L, 304V stainless steel, Co-Cr-Mo alloy, pure titanium, Ti-6Al-4V, TiNi alloy, etc. These materials are non-degradable in the hum...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C23C22/13C23C22/83C23C22/68A61L27/04A61L27/32A61L27/58A61L31/02A61L31/08A61L31/14
CPCA61L27/047A61L27/32A61L27/58A61L31/022A61L31/086A61L31/148A61L2420/02A61L2420/06A61L2430/02C23C22/13C23C22/68C23C22/83
Inventor 李华芳郑宜星林桂彩黄金燕王鹏宇纪晓静王鲁宁
Owner UNIV OF SCI & TECH BEIJING
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