Multi-ion co-doped tetracalcium phosphate powder, synthetic method and application

A technology of tetracalcium phosphate powder and tetracalcium phosphate, which is applied in the direction of phosphorus compounds, chemical instruments and methods, prostheses, etc., and can solve the problems of unfavorable bone cell proliferation and other problems

Active Publication Date: 2021-01-05
SUZHOU DINGAN ELECTRONICS TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The invention discloses a multi-ion co-doped tetracalcium phosphate powder, which solves the problem in the prior art that the pH of

Method used

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  • Multi-ion co-doped tetracalcium phosphate powder, synthetic method and application
  • Multi-ion co-doped tetracalcium phosphate powder, synthetic method and application
  • Multi-ion co-doped tetracalcium phosphate powder, synthetic method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0053] Example 1Ca 3.2 Sr 0.5 Mg 0.2 Zn 0.1 (PO 4 ) 1.9 (SiO 4 ) 0.1 O powder

[0054] Weigh 5.631gCa(OH) 2 , 2.214gSrCO 3 , 0.890gMg(NO 3 ) 2 and 0.892gZn(NO 3 ) 2 ·6H 2 O was dissolved in 100ml of deionized water to prepare a multi-ion mixed solution L1, and 30ml of concentrated ammonia water was added to control the pH at about 8, and stirred in a water bath at 40°C for 30min; take 5.586gH 3 PO 4 and 0.552gNa 4 SiO 4 Dissolved in 50ml of deionized water to prepare phosphorus-containing and silicate mixed solution L2; under 25kHz, 500W ultrasonic assisted conditions, the L2 solution was added dropwise to the L1 solution at a rate of 2.5ml / min, and mixed and stirred for 2 hours to obtain Multi-ion co-doped hydroxyapatite Ca 7.6 Sr 1.5 Mg 0.6 Zn 0.3 (PO 4 ) 5.7 (SiO 4 ) 0.3 (OH) 2 Suspension L3. Then, weigh 4.723g Ca (NO 3 ) 2

[0055] 4H 2 O and 2.12gNa 2 CO 3 , add 20ml of deionized water to make a solution, and under the condition of 25kHz, ...

Embodiment 2

[0061] Example 2Ca 3.3 Sr 0.2 mn 0.2 co 0.2 Cu 0.1 (PO 4 ) 1.8 (SiO 4 ) 0.2 O powder

[0062] Weigh 5.854gCa(OH) 2 , 0.886gSrCO 3 , 1.074gMn(NO 3 ) 2 , 0.563gCu(NO 3 ) 2 and 1.746gCo(NO 3 ) 2 ·

[0063] 6H 2Dissolve O in 100ml of deionized water to prepare a multi-ion mixed solution L1, add 30ml of concentrated ammonia water, control the pH at about 8, and stir in a water bath at 60°C for 30min. Take 5.292gH 3 PO 4 and 0.732gNa 2 SiO 3 Dissolved in 46ml of deionized water to form a mixed solution of phosphorus and silicate ions L2, under 25kHz, 500W ultrasonic assisted conditions, the L2 solution was added dropwise to the L1 solution at a rate of 4ml / min, and mixed and stirred for 3.5 hours to obtain poly Ionic co-doped hydroxyapatite Ca 7.9

[0064] Sr 0.6 mn 0.6 co 0.6 Cu 0.3 (PO 4 ) 5.4 (SiO 4 ) 0.6 (OH) 2 Suspension L3. Weigh 4.723gCa(NO 3 ) 2 4H 2 O and 1.680 g NaHCO 3 , adding 20ml of deionized water to form a solution, and under the...

Embodiment 3

[0068] Example 3Ca 2.8 Mg 0.5 Fe 0.3 co 0.2 Cu 0.1 Zn 0.1 (PO 4 ) 1.7 (SiO 4 ) 0.3 O powder

[0069] Weigh 4.742gCa(OH) 2 , 2.225gMg(NO 3 ) 2 , 1.619gFe(NO 3 ) 3 , 0.892gZn (NO 3 ) 2 ·6H 2 O, 1.746gCo(NO 3 ) 2 ·6H 2 O and 0.563gCu(NO 3 ) 2 Dissolve in 100ml of deionized water to make a multi-ion mixed solution L1, add 30ml of concentrated ammonia water, control the pH value to 7~8, stir in a 50°C water bath for 30min. Take 4.998gH 3 PO 4 and 1.099gNa 2 SiO 3 Dissolved in 48ml of deionized water to form a mixed solution L2 containing phosphorus and silicon ions. Under 25kHz, 500W ultrasonic assisted conditions, the L2 solution was added dropwise to the L1 solution at a rate of 3ml / min, and mixed and stirred for 4 hours to obtain multiple Ionic co-doped hydroxyapatite Ca 6.4 Mg 1.5 Fe 0.9 co 0.6 Cu 0.3 Zn 0.3 (PO 4 ) 5.1 (SiO 4 ) 0.9 (OH) 2 Suspension L3. Weigh 3.1634gCa(CH 3 COO) 2 and 1.92g (NH 4 ) 2 CO 3 , add 30ml of deionized water...

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Abstract

The invention relates to the field of biomedical materials, and particularly discloses multi-ion co-doped tetracalcium phosphate powder, a synthesis method and application. The problems that in the prior art, the pH value of a traditional tetracalcium phosphate hydration product is larger than 12, bone cell proliferation is not facilitated, multiple biological properties such as bone conduction, bone induction and vascularization promotion do not exist, and bacteria resistance and bacteriostasis cannot be achieved are solved. The preparation method comprises: in-situ synthesizing multi-ion co-doped tetracalcium phosphate precursor composite powder by adopting an ultrasonic-assisted two-step liquid-phase chemical precipitation method, and then carrying out ultrasonic-assisted rapid cyclic calcination and cooling to obtain the multi-ion co-doped tetracalcium phosphate powder with the general formula of Ca4xMx(PO4)2yz(SiO4)y(BO3)zO, wherein (Ca + M)/(P + Si + B) = 2 +/-0.2. According to the invention, by doping boron ions, the pH value of a tetracalcium phosphate hydration product microenvironment can be effectively regulated and controlled, and bone cell proliferation is facilitated;the obtained product has the advantages of high phase purity, fine crystal grains, high hydration activity and controllable crystallinity, and is suitable for hard tissue repair.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a multi-ion co-doped tetracalcium phosphate powder, a synthesis method and an application. Background technique [0002] It is well known that tetracalcium phosphate Ca 4 (PO 4 ) 2 O (Tetcalcium phosphate, referred to as TTCP) is the main component of calcium phosphate cement (Calcium phosphate cement, referred to as CPC), which has obvious hydration properties. The bone-like apatite formed by TTCP hydration has a microstructure and chemical composition similar to the mineral composition of natural bone, and can form chemical bonds with natural bone. Therefore, the CPC produced by using TTCP as the main raw material not only has good biocompatibility and osteoconductivity, but also is easy to be molded or injected. It can be accurately shaped and filled according to the bone defect site or directly injected into the bone defect site in the body, and quickly Solidification ...

Claims

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Application Information

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IPC IPC(8): C01B33/20C01B25/45A61L27/12A61L27/02A61L27/50A61L27/54
CPCC01B33/20C01B25/45A61L27/12A61L27/025A61L27/50A61L27/54C01P2002/72A61L2430/12A61L2430/02A61L2430/38A61L2430/24A61L2300/104A61L2300/102A61L2300/112A61L2300/404A61L2300/412A61L2400/12
Inventor 朱阳光杨志杰李亚东李亚军
Owner SUZHOU DINGAN ELECTRONICS TECH
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