Compound temperature-sensitive gel spray for treating herpes zoster and preparation method thereof

A herpes zoster and temperature-sensitive technology, applied in the field of medicine, can solve problems such as the difficulty of medication for patients

Inactive Publication Date: 2021-07-30
WUXI JIYU SHANHE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the common dosage forms of the above-mentioned medicines for external use are also ointments, which need to be repeatedly applied to the affected area, causing difficulty in medication for patients

Method used

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  • Compound temperature-sensitive gel spray for treating herpes zoster and preparation method thereof
  • Compound temperature-sensitive gel spray for treating herpes zoster and preparation method thereof
  • Compound temperature-sensitive gel spray for treating herpes zoster and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Acyclovir 3%, etimicin sulfate 5%, poloxamer 407 18%, poloxamer 188 8%, adhesive 2%, and the rest are water.

[0043] Adhesive hypromellose.

[0044] Preparation:

[0045] (1) Acyclovir and etimicin sulfate of prescription quantity are taken and dissolved in water for injection, cooled for subsequent use;

[0046] (2) Dissolve the adhesive agent of prescription quantity in solution (1), for subsequent use;

[0047] (3) Slowly add the prescribed amount of Poloxamer 407 and Poloxamer 188 into the solution (2), refrigerate and swell at 4°C, stir until uniform, add cold water for injection to 1000ml, and the solution is ready.

Embodiment 2

[0049] Acyclovir 3%, etimicin sulfate 5%, poloxamer 407 20%, poloxamer 188 5%, adhesive 3%, osmotic pressure regulator 0.9%, preservative 0.03%, the rest Both are water.

[0050] Adhesive Carbomer.

[0051] Preparation:

[0052] (1) Acyclovir and etimicin sulfate of prescription quantity are taken and dissolved in water for injection, cooled for subsequent use;

[0053] (2) Dissolve the adhesive agent of prescription quantity in solution (1), for subsequent use;

[0054] (3) Slowly add the prescribed amount of Poloxamer 407 and Poloxamer 188 into the solution (2), refrigerate and swell at 4°C, stir until uniform, add cold water for injection to 1000ml, and the solution is ready.

Embodiment 3

[0056] Acyclovir 3%, etimicin sulfate 5%, poloxamer 407 15%, poloxamer 188 15%, adhesive 1%, and the rest are water.

[0057] Adhesive hypromellose;

[0058] Preparation:

[0059] (1) Acyclovir and etimicin sulfate of prescription quantity are taken and dissolved in water for injection, cooled for subsequent use;

[0060] (2) dissolving the prescription amount in solution (1), for subsequent use;

[0061] (3) Slowly add the prescribed amount of Poloxamer 407 and Poloxamer 188 into the solution (2), refrigerate and swell at 4°C, stir until uniform, add cold water for injection to 1000ml, and the solution is ready.

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PUM

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Abstract

The invention relates to a compound temperature-sensitive type gel spraying agent for treating herpes zoster and a preparation method of the compound temperature-sensitive type gel spraying agent, and the compound temperature-sensitive type gel spraying agent is prepared from the following components in percentage by weight, which are shown in the description.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a compound temperature-sensitive gel spray for treating herpes zoster and a preparation method thereof. Background technique [0002] Herpes zoster is an acute infectious skin disease caused by the varicella-zoster virus. Because the virus is neurotropic, it can remain dormant in the neurons of the dorsal root ganglia of the spinal cord for a long time. When the resistance is low or when you are tired, infected, or caught a cold, the virus can grow and multiply again, and move to the skin along the nerve fibers, causing Intense inflammation of the affected nerves and skin. The affected area often appears first with erythema, followed by miliary to soybean-sized papules, which are distributed in clusters without fusion, and then quickly turn into blisters, with tense and shiny walls, clear blister fluid, and blush around the periphery. The skin in the middle is normal; neuralg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K9/06A61K31/7036A61K31/522A61K47/10A61P31/22
CPCA61K9/12A61K9/06A61K9/0014A61K31/7036A61K31/522A61K47/10A61P31/22
Inventor 刘薇薇俞婷王丹丹周雪姣
Owner WUXI JIYU SHANHE PHARM CO LTD
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