Unlock instant, AI-driven research and patent intelligence for your innovation.
Composition with function of enhancing phagocytic activity of macrophages, application thereof, and immune medicine
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of macrophages and compositions, applied in the field of medicine, can solve problems such as limitations
Active Publication Date: 2021-07-30
国珍健康科技(北京)有限公司
View PDF2 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
However, the current stimulating substances are relatively limited, and the effect of enhancing the phagocytic ability of macrophages is given priority. It is necessary to find other substances that can improve the phagocytic activity of macrophages
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
preparation example Construction
[0051] In a preferred embodiment, the preparation method of the pine flower aqueous extract comprises the steps:
[0052] The preparation method of described pine flower aqueous extract comprises the steps:
[0053] mixing pine pollen with water, and ultrasonically preparing the pine flower water extract under heating conditions;
[0054] Preferably, the mass ratio of the pine pollen to water is 1:(8-12), for example, but not limited to 1:8, 1:9, 1:10, 1:11 or 1:12, preferably 1:10;
[0055] Preferably, the heating temperature is 25-45°C, for example, but not limited to 25°C, 30°C, 35°C, 40°C or 45°C, preferably 37°C;
[0056] Preferably, the ultrasonic time is 10-30 minutes, for example, but not limited to 10 minutes, 15 minutes, 20 minutes, 25 minutes or 30 minutes, preferably 20 minutes.
[0057] In the present invention, by further optimizing and adjusting the preparation method of the pine flower water extract, the extraction of effective substances in the pine pollen is...
[0079] (1) Fucoidan: Take 200mg of fucoidan in 2ml of hot water, ultrasonically dissolve it for 10 minutes, pass through a 0.22μm filter membrane to make a 100mg / ml stock solution of fucoidan, and store it in a refrigerator at 5°C for later use.
[0080] (2) Elderberry: Weida International Co., Ltd., containing 10% anthocyanins, prepared 40mg / ml elderberry stock, dissolved 200mg extract in 5ml water, sterilized through a 0.22μm filter membrane, -20℃ Store for later use.
[0082] (4) Songhua water extract: Take 500mg of pine pollen in 5ml of water, bathe at 37°C, ultrasonicate for 20min, pass through a 0.22μm filter membrane to make 100mg / ml Songhua water extract stock solution, put it in a refr...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Login to View More
Abstract
The invention provides a composition with a function of enhancing phagocytic activity of macrophages, application thereof, and an immune medicine, and relates to the technical field of medicines. The composition with the function of enhancing the phagocytic activity of the macrophages, provided by the invention, comprises fucoidan and elderberry, and the inventor finds that the fucoidan and the elderberry both have an immunoregulation function and can enhance the phagocytic activity of the macrophages and inhibit lipopolysaccharide from inducing the macrophages to secrete nitric oxide, the effect of enhancing the phagocytic activity of the macrophages by jointly using the fucoidan and the elderberry is obviously better than that of a single component, the fucoidan and the elderberry have a synergistic effect, and the fucoidan and the elderberry are safe and reliable and can be used for preparing the medicine for enhancing the phagocytic activity of the macrophages.
Description
technical field [0001] The invention relates to the technical field of medicine, in particular to a composition capable of enhancing the phagocytic activity of macrophages, its application and immune medicine. Background technique [0002] Macrophages (Macrophages) are white blood cells located in tissues, derived from monocytes, and play an important role in body development, immunity, inflammatory response and the occurrence of various diseases by phagocytizing autologous damaged cells or foreign pathogens. That said, they are involved in nearly every human disease and they are also major therapeutic targets because their function can be enhanced or inhibited to alter disease outcome. Therefore, improving the phagocytic activity of macrophages is helpful to the improvement of the body's immune level and the treatment of various diseases. [0003] Existing studies have shown that macrophages in living organisms can change their phenotype and immune function with changes in...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More 
Login to View More 
