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Oral suspension of gleptoferron and ponazuril and preparation method thereof

A technology of iron glucoheptose and suspension, which is applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, blood diseases, etc., which can solve the problem of increasing drug costs, affecting animal growth and development, and affecting breeding Economic benefits and other issues, to achieve the effect of improving animal welfare, reducing the workload of drug administration, and reducing the amount of excipients

Pending Publication Date: 2021-08-03
HUBEI LONGXIANG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] This single-disease, single-treatment model brings a huge workload to farming, increases the cost of medicines, and at the same time puts enormous pressure on animals, affecting the normal growth and development of animals, and will eventually affect the economic benefits of farming.

Method used

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  • Oral suspension of gleptoferron and ponazuril and preparation method thereof
  • Oral suspension of gleptoferron and ponazuril and preparation method thereof
  • Oral suspension of gleptoferron and ponazuril and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Example 1 Preparation of Oral Suspension 1 Containing Patopazuril and Iron Glucoheptose

[0069] 1. Prescription composition:

[0070]

[0071] 2. Preparation method:

[0072] S1. Take an appropriate amount of purified water into the liquid mixing tank, and add the prescribed amount of iron glucoheptose in 1 to 5 times. After all the input, use a high-shear emulsifier at 3000 to 6000 rpm at 65 to 75 ° C. Minute speed stirring 30min, obtain initial solution;

[0073] S2. After cooling the initial solution to room temperature, add the prescribed amount of preservatives sodium benzoate, edetate disodium, and Avicel, and fully stir and dissolve to obtain a suspension I;

[0074] S3. Add the prescribed amount of Patopazuril to the above suspension I, and after dispersion, stir with a high-shear emulsifier at a speed of 4000 to 5000 rpm for 30 minutes to obtain a uniformly dispersed suspension II;

[0075] S4. Put the prescribed amount of citric acid into the above susp...

Embodiment 2

[0077] Example 2 Preparation of Oral Suspension 2 Containing Patopazuril and Iron Glucoheptan

[0078] 1. Prescription composition:

[0079]

[0080] 2. The preparation method is the same as in Example 1.

Embodiment 3

[0081] Example 3 Preparation of Oral Suspension 3 Containing Patopazuril and Iron Glucoheptan

[0082] 1. Prescription composition:

[0083]

[0084] Preparation method is the same as embodiment 1

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Abstract

The invention relates to a composition containing gleptoferron and ponazuril, wherein the weight ratio of ponazuril to gleptoferron (based on active iron) is (1: 2)-(1: 5). The composition can be prepared into oral suspension. The composition is stable in preparation and good in safety, and can be used for preventing and treating coccidiosis infection and iron-deficiency anemia of animals at the same time.

Description

technical field [0001] The invention belongs to the technical field of veterinary drugs, and in particular relates to an oral suspension containing iron glucoheptonate and patopazuril and a preparation method thereof, which are suitable for simultaneously preventing and treating coccidiosis and iron deficiency in animals. Background technique [0002] Coccidiosis and iron deficiency anemia are frequent animal diseases in the process of modern animal husbandry. They occur frequently in young animals. The incidence is high and the disease aggravates rapidly, seriously affecting the growth and development of animals, and even causing death. [0003] Piglets have very limited iron storage (40-50 mg) at birth and iron (about 1 mg / d) obtained from breast milk during lactation, which leads to iron deficiency in piglets in the first week after birth. Clinically, intramuscular injection of iron or indirect iron supplementation to sows is mainly used. Since the amount of iron suppleme...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/7032A61K33/26A61K31/53A61K47/38A61K47/18A61P33/02A61P7/06A61P3/02
CPCA61K9/10A61K9/0053A61K31/53A61K31/7032A61K33/26A61K47/38A61K47/183A61P33/02A61P7/06A61P3/02A61K2300/00
Inventor 卢山陈清平王铭宏
Owner HUBEI LONGXIANG PHARMA TECH CO LTD
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