Vorinostat skeleton-based anthranilamide compound as well as preparation and application thereof

A technology of aminobenzamide and vorinostat, which is applied in the field of medicine, can solve the problems of neutropenia and leukopenia, achieve high yield, inhibit the proliferation of gastric cancer cells, and have simple and efficient preparation methods
CN113200885AActive Publication Date: 2021-08-03NANHUA UNIV
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Patent Information

Authority / Receiving Office
CN ยท China
Current Assignee / Owner
NANHUA UNIV
Publication Date
2021-08-03

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Abstract

The invention provides a vorinostat skeleton-based anthranilamide compound as well as preparation and application of the anthranilamide compound. The structural formula of the o-aminobenzamide compound based on a vorinostat skeleton is shown in the specification, wherein n is equal to 1-6, and R is methylamino, dimethylamino, hydroxyl, NH2 or the like. The anthranilamide compound based on the vorinostat skeleton has the effect of inhibiting gastric cancer cell proliferation through MTT method determination, and can be used for preparing anti-gastric cancer drugs.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a vorinostat skeleton-based anthranilamide compound and a preparation method thereof, and also relates to the application of the compound in the preparation of anti-gastric cancer drugs. Background technique

[0002] Tumor is the second killer that seriously threatens human life and health after cardiovascular and cerebrovascular diseases. In 2018, there were 18.1 million new cases of cancer worldwide and 9.6 million deaths from it. Among them, the incidence rate of gastric cancer ranks fifth, and the mortality rate ranks third. According to statistics, in 2018, there were 1.03 million new cases of gastric cancer worldwide and 783,000 deaths, which is equivalent to 1 case of gastric cancer in every 12 deaths caused by malignant tumors in the world. As a large gastric cancer country, China accounts for more than 40% of the total number of gastric cancer deaths in th...

Claims

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