Application of small molecule compound in preparation of anti-depression drug

A small molecule compound, antidepressant technology, applied in the field of medicine, can solve the problems of large side effects, unsatisfactory drug requirements, poor specificity of MIF inhibitor NAPQI, etc., and achieves the effect of low cytotoxicity and good development prospects.

Active Publication Date: 2021-08-06
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The first discovered MIF inhibitor NAPQI has poor specificity and side effects
The pharmacokinetic properties of 4-IPP inhibitors are poor and do not meet the conditions for drug preparation

Method used

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  • Application of small molecule compound in preparation of anti-depression drug
  • Application of small molecule compound in preparation of anti-depression drug
  • Application of small molecule compound in preparation of anti-depression drug

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Embodiment Construction

[0017] In order to make the above objects, features and advantages of the present invention more obvious and comprehensible, the technical solution of the present invention will be further described below in conjunction with the examples. But the present invention is not limited to the listed embodiments, but also includes any other known changes within the claimed scope of the present invention.

[0018] Reference herein to "one embodiment" or "an embodiment" refers to a particular feature, structure or characteristic that can be included in at least one implementation of the present invention. "In one embodiment" appearing in different places in this specification does not all refer to the same embodiment, nor is it a separate or selective embodiment that is mutually exclusive with other embodiments.

[0019] The present invention discovers the small molecule compound N-(2-(1-(4-chlorophenyl)-5-hydroxyl-3-phenyl-1hydrogen-pyrazol-4-yl) through virtual screening software base...

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Abstract

The invention discloses an application of a small molecule compound, the small molecule compound is N-(2-(1-(4-chlorphenyl)-5-hydroxy-3-phenyl-1-hydro-pyrazole-4-yl)-2-acetyl)-4-methyl-N-propyl benzamide, the chemical structural formula of the small molecule compound is shown in the specification, and the small molecule compound has a relatively strong inhibition effect on MIF. The small molecule compound has obvious inhibition effect on microglial cell activation and inflammatory factor release, has low cytotoxicity, has good development prospect, is expected to be developed into a novel MIF inhibitor, is expected to be developed into a novel medicine for resisting central system inflammation, and especially is expected to be developed into a novel medicine for treating depression.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of a small molecular compound in the preparation of MIF inhibitors and antidepressant drugs. Background technique [0002] Depression is the most prevalent mental illness in today's society. According to statistics from the World Health Organization (WHO) in 2019, there are more than 350 million depressed patients worldwide, and as many as 1 million people commit suicide due to depression every year. Treatment for depression is urgent. In addition to the classic monoamine hypothesis, central nervous system immune dysregulation plays a key role in it. Microglia are the main immune cells of the nervous system, and when stimulated by signals, the resting microglia are activated into the classically activated M1 type or the selectively activated M2 type. M1 microglia secrete iNOS, TNF-α, ROS and other pro-inflammatory factors, which play an important ro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/415A61P25/24
CPCA61K31/415A61P25/24
Inventor 镇学初田盛刘纯
Owner SUZHOU UNIV
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